Evidence map›Paper›PMID 36016877›Full record

ArticleFrontiers in pediatrics2022

Fecal calprotectin levels in pediatric cow's milk protein allergy.

Dominika Lendvai-Emmert, Vanessza Emmert, Alexandra Makai, Katalin Fusz, Viktória Prémusz, Kata Eklics, Patrícia Sarlós, Péter Tóth, Krisztina Amrein, Gergely Tóth

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Cow milk protein allergy mimics in infancy.World journal of clinical pediatrics · 2025
    Review
  5. Observational
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Dominika Lendvai-EmmertDoctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.
Vanessza EmmertDoctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.
Alexandra MakaiDoctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.
Katalin FuszDepartment of Physiology, Medical School, University of Pécs, Pécs, Hungary.
Viktória PrémuszDoctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.
Kata EklicsDepartment of Languages for Biomedical Purposes, University of Pécs, Pécs, Hungary.
Patrícia SarlósFirst Department of Medicine, Medical School, University of Pécs, Pécs, Hungary.
Péter TóthDepartment of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary.
Krisztina AmreinDepartment of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary.
Gergely TóthDoctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.
University of Pecs · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The most prevalent food allergy in younger children is cow's milk protein allergy (CMPA), a hypersensitivity reaction to cow's milk protein and its most common clinical manifestation is allergic colitis. The goal of our recent study was to assess somatic symptoms of CMPA and to prospectively observe the effects of a dairy elimination diet using objective parameters and questionnaires. Methods: The County Hospital in Szekszárd, Hungary, investigated children aged 1 to 18 who had clinical signs that might indicate CMPA. Stool samples were taken and analyzed using a fecal calprotectin (FC) rapid test (Quantum Blue fCAL, Bühlmann Laboratories, Switzerland) at the time of the diagnosis and following 3 months of an elimination diet. At the baseline visit as well as the first and second follow-up, questionnaires were filled out. Patients were divided into two subgroups according to dietary guidelines based on the results of the questionnaires. Results: A total of 47 patients participated in the study [42.55% female, mean age: 7.36 (SD 4.22) years]. There was no significant difference in FC levels between baseline and after 3-month elimination diet [73.98 (71.12) μg/g and 68.11 (74.4) μg/g, respectively, Conclusion: The findings of our study suggest that FC can be an objective marker in confirming the diagnosis of CMPA. Significant improvement in clinical symptoms and in FC levels can only be expected after a strictly followed elimination diet.

Indexed as

childrencow's milk protein allergydairyelimination dietfecal calprotectinfood allergyGastroenterology

Identifiers

PMID36016877
PMCPMC9397604
OpenAlexW4290729324

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.