Evidence map›Paper›PMID 36016668›Full record

ReviewPulmonary circulation2022

Clinical significance of pulmonary hypertension in interstitial lung disease: A consensus statement from the Pulmonary Vascular Research Institute's innovative drug development initiative-Group 3 pulmonary hypertension.

Sylvia M Nikkho, Manuel J Richter, Eric Shen, Steven H Abman, Katerina Antoniou, Jonathan Chung, Peter Fernandes, Paul Hassoun, Howard M Lazarus, Horst Olschewski and 9 more

Open access · goldAbstract readReview
In one paragraph

Review in Pulmonary circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
8.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
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  13. Review
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  15. Haemodynamics and post-exercise recovery response in COPD-PH and ILD-PH: An appraisal.Lung India : official organ of Indian Chest Society · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 16 institutions in 7 countries.

Sylvia M NikkhoGlobal Clinical Development Bayer AG Berlin Germany.ORCID 0000-0003-1245-2656
Manuel J RichterDepartment of Internal Medicine Pulmonary Hypertension Division Universities of Giessen and Marburg Lung Center (UGMLC) Giessen Germany.ORCID 0000-0003-0964-1931
Eric ShenGlobal Medical Affairs United Therapeutics Corporation Silver Spring Maryland USA.ORCID 0000-0001-5621-6570
Steven H AbmanSchool of Medicine and Children's Hospital University of Colorado-Anschutz Medical Campus Aurora Colorado USA.
Katerina AntoniouDepartment of Thoracic Medicine University of Crete School of Medicine Heraklion Crete Greece.
Jonathan ChungDepartment of Radiology The University of Chicago Medicine Chicago Illinois USA.
Peter FernandesRegulatory, Safety and Quality Department Bellerophon Therapeutics Inc Warren New Jersey USA.
Paul HassounDepartment of Medicine, Division of Pulmonary and Critical Care Medicine Johns Hopkins University Baltimore Maryland USA.
Howard M LazarusAltavant Sciences Cary North Carolina USA.ORCID 0000-0001-8231-3710
Horst OlschewskiDivision of Pulmonology, Department of Internal Medicine Medical University of Graz Graz Steiermark Austria.
Lucilla PiccariDepartment of Pulmonary Medicine Hospital del Mar, Pulmonary Hypertension Unit Barcelona Catalunya Spain.
Mitchell PsotkaInova Heart and Vascular Institute Falls Church Virginia USA.
Rajan SaggarLung & Heart-Lung Transplant and Pulmonary Hypertension Programs University of California Los Angeles David Geffen School of Medicine Los Angeles California USA.
Oksana A ShlobinAdvanced Lung Disease and Transplant Program Inova Heart and Vascular Institute Falls Church Virginia USA.
Norman StockbridgeDivision of Cardiology and Nephrology US Food and Drug Administration Silver Spring Maryland USA.
Patrizio VituloTherapies, Department of Pulmonary Medicine IRCCS Mediterranean Institute for Transplantation and Advanced Specialized Palermo Sicilia Italy.
Carmine Dario VizzaPulmonary Hypertension Unit University of Rome La Sapienza Rome Lazio Italy.
Stephen J WortNational Pulmonary Hypertension Service at Royal Brompton Hospital London UK.
Steven D NathanAdvanced Lung Disease and Transplant Program Inova Heart and Vascular Institute Falls Church Virginia USA.ORCID 0000-0002-6270-1617
Inova Fairfax Hospital · USUnited States Food and Drug Administration · USBayer (Germany) · DEBellerophon Therapeutics (United States) · USChildren's Hospital Colorado · USIstituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione · ITJohns Hopkins University · USMedical University of Graz · ATPulmonary Hypertension Association · USRoyal Brompton Hospital · GBSapienza University of Rome · ITUnited Therapeutics (United States) · USUniversities of Giessen and Marburg Lung Center · DEUniversity of California, Los Angeles · USUniversity of Chicago · USUniversity of Crete · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary hypertension (PH) has been linked to worse outcomes in chronic lung diseases. The presence of PH in the setting of underlying Interstitial Lung Disease (ILD) is strongly associated with decreased exercise and functional capacity, an increased risk of hospitalizations and death. Examining the scope of this issue and its impact on patients is the first step in trying to define a roadmap to facilitate and encourage future research in this area. The aim of our working group is to strengthen the communities understanding of PH due to lung diseases and to improve the care and quality of life of affected patients. This introductory statement provides a broad overview and lays the foundation for further in-depth papers on specific topics pertaining to PH-ILD.

Indexed as

epidemiologyinterstitial lung diseaseprognosispulmonary hypertensionsymptom assessment and management

Identifiers

PMID36016668
PMCPMC9395696
OpenAlexW4290840334

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.