Evidence map›Paper›PMID 36016652›Full record

ArticleFrontiers in cell and developmental biology2022

A Stable Chemokine Gradient Controls Directional Persistence of Migrating Dendritic Cells.

Thomas Quast, Karolin Zölzer, Donald Guu, Luis Alvarez, Carsten Küsters, Eva Kiermaier, U Benjamin Kaupp, Waldemar Kolanus

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Thomas QuastMolecular Immunology and Cell Biology, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.
Karolin ZölzerMolecular Immunology and Cell Biology, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.
Donald GuuMolecular Sensory Systems, Max Planck Institute for Neurobiology of Behavior-Caesar, Bonn, Germany.
Luis AlvarezMolecular Sensory Systems, Max Planck Institute for Neurobiology of Behavior-Caesar, Bonn, Germany.
Carsten KüstersMolecular Immunology and Cell Biology, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.
Eva KiermaierImmune and Tumor Biology, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.
U Benjamin KauppMolecular Sensory Systems, Max Planck Institute for Neurobiology of Behavior-Caesar, Bonn, Germany.
Waldemar KolanusMolecular Immunology and Cell Biology, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.
University of Bonn · DEMax Planck Institute for Neurobiology of Behavior – caesar

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Navigation of dendritic cells (DCs) from the site of infection to lymphoid organs is guided by concentration gradients of CCR7 ligands. How cells interpret chemokine gradients and how they couple directional sensing to polarization and persistent chemotaxis has remained largely elusive. Previous experimental systems were limited in the ability to control fast

Indexed as

chemotaxisdendritic cellsdirectional sensinggradientleukocytes

Identifiers

PMID36016652
PMCPMC9395945
OpenAlexW4292457778

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.