Evidence map›Paper›PMID 36016408›Full record

ReviewViruses2022

Chikungunya Immunopathology as It Presents in Different Organ Systems.

Elizabeth M Traverse, Erin M Millsapps, Emma C Underwood, Hannah K Hopkins, Makenzie Young, Kelli L Barr

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Bone erosions and joint damage caused by chikungunya virus: a systematic review.Revista da Sociedade Brasileira de Medicina Tropical · 2024
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Infectomics of Chikungunya Virus: Roles Played by Host Factors.The American journal of tropical medicine and hygiene · 2025
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Extra-articular Manifestations of Chikungunya.Revista da Sociedade Brasileira de Medicina Tropical · 2023
    Review
  17. Article
  18. Common arboviruses and the kidney: a review.Jornal brasileiro de nefrologia
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Elizabeth M TraverseCenter for Global Health and Infectious Disease Research, University of South Florida, Tampa, FL 33612, USA.
Erin M MillsappsCenter for Global Health and Infectious Disease Research, University of South Florida, Tampa, FL 33612, USA.
Emma C UnderwoodCenter for Global Health and Infectious Disease Research, University of South Florida, Tampa, FL 33612, USA.
Hannah K HopkinsCenter for Global Health and Infectious Disease Research, University of South Florida, Tampa, FL 33612, USA.
Makenzie YoungCenter for Global Health and Infectious Disease Research, University of South Florida, Tampa, FL 33612, USA.
Kelli L BarrCenter for Global Health and Infectious Disease Research, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0001-7943-7181
University of South Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chikungunya virus (CHIKV) is currently an urgent public health problem as high morbidity from the virus leaves populations with negative physical, social, and economic impacts. CHIKV has the potential to affect every organ of an individual, leaving patients with lifelong impairments which negatively affect their quality of life. In this review, we show the importance of CHIKV in research and public health by demonstrating the immunopathology of CHIKV as it presents in different organ systems. Papers used in this review were found on PubMed, using "chikungunya and [relevant organ system]". There is a significant inflammatory response during CHIKV infection which affects several organ systems, such as the brain, heart, lungs, kidneys, skin, and joints, and the immune response to CHIKV in each organ system is unique. Whilst there is clinical evidence to suggest that serious complications can occur, there is ultimately a lack of understanding of how CHIKV can affect different organ systems. It is important for clinicians to understand the risks to their patients.

Indexed as

Chikungunya FeverChikungunya virusHumansQuality of Lifearthritiscardiacchikungunyacutaneousimmunologyimmunopathogenesisjointsneurologicalrenalrespiratory

Identifiers

PMID36016408
PMCPMC9414582
OpenAlexW4292317222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.