Evidence map›Paper›PMID 36016349›Full record

ArticleViruses2022

Zika Virus (ZIKV): A New Perspective on the Nanomechanical and Structural Properties.

Maria Luiza de Araujo Dorneles, Ruana Cardoso-Lima, Pedro Filho Noronha Souza, Daniela Santoro Rosa, Tais Monteiro Magne, Ralph Santos-Oliveira, Luciana Magalhães Rebelo Alencar

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Maria Luiza de Araujo DornelesLaboratory of Biophysics and Nanosystems, Physics Department, Federal University of Maranhão, São Luís 65020070, Brazil.ORCID 0000-0003-3893-1292
Ruana Cardoso-LimaLaboratory of Biophysics and Nanosystems, Physics Department, Federal University of Maranhão, São Luís 65020070, Brazil.ORCID 0000-0003-0952-3927
Pedro Filho Noronha SouzaDepartment of Biochemistry, Federal University of Ceará, Fortaleza 60440900, Brazil.ORCID 0000-0003-2524-4434
Daniela Santoro RosaDepartment of Microbiology, Immunology, and Parasitology, Federal University of São Paulo, São Paulo 04023062, Brazil.ORCID 0000-0003-4536-891X
Tais Monteiro MagneBrazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro 21941906, Brazil.ORCID 0000-0003-3416-054X
Ralph Santos-OliveiraBrazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro 21941906, Brazil.ORCID 0000-0002-0905-481X
Luciana Magalhães Rebelo AlencarLaboratory of Biophysics and Nanosystems, Physics Department, Federal University of Maranhão, São Luís 65020070, Brazil.ORCID 0000-0001-8210-2016
Universidade Federal do Maranhão · BRNuclear Engineering Institute · BRUniversidade do Estado do Rio de Janeiro · BRUniversidade Federal de São Paulo · BRUniversidade Federal do Ceará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) from Flavivirus. In 2015, Brazil and other Latin American countries experienced an outbreak of ZIKV infections associated with severe neurological disorders such as Guillain-Barre syndrome (GBS), encephalopathy, and encephalitis. Here, a complete mechanical and structural analysis of the ZIKV has been performed using Atomic Force Microscopy (AFM). AFM analysis corroborated the virus mean size (~50 nm) and icosahedral geometry and revealed high mechanical resistance of both: the viral surface particle (~200 kPa) and its internal content (~800 kPa). The analysis demonstrated the detailed organization of the nucleocapsid structure (such as RNA strips). An interesting finding was the discovery that ZIKV has no surface self-assembling property. These results can contribute to the development of future treatment candidates and circumscribe the magnitude of viral transmission.

Indexed as

Zika VirusZika Virus InfectionBrazilDisease OutbreaksHumansMicroscopy, Atomic ForceAFMarbovirusphysical virologyultrastructureZIKV

Identifiers

PMID36016349
PMCPMC9414353
OpenAlexW4292512979

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.