Evidence map›Paper›PMID 36016233›Full record

ReviewVaccines2022

The SARS-CoV-2 Antibodies, Their Diagnostic Utility, and Their Potential for Vaccine Development.

Khalid Hajissa, Ali Mussa, Mohmed Isaqali Karobari, Muhammad Adamu Abbas, Ibrahim Khider Ibrahim, Ali A Assiry, Azhar Iqbal, Saad Alhumaid, Abbas Al Mutair, Ali A Rabaan and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 10 countries.

Khalid HajissaDepartment of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Kelantan, Malaysia.ORCID 0000-0002-1725-6702
Ali MussaDepartment of Haematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Kelantan, Malaysia.ORCID 0000-0002-1116-7362
Mohmed Isaqali KarobariConservative Dentistry Unit, School of Dental Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kota Bharu 16150, Kelantan, Malaysia.ORCID 0000-0002-0313-9695
Muhammad Adamu AbbasDepartment of Medical Microbiology and Parasitology, College of Health Sciences, Bayero University Kano, Kano 3011, Nigeria.ORCID 0000-0003-1767-4629
Ibrahim Khider IbrahimDepartment of Haematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum 11111, Sudan.ORCID 0000-0002-8223-5369
Ali A AssiryPreventive Dental Science Department, Faculty of Dentistry, Najran University, Najran 55461, Saudi Arabia.ORCID 0000-0002-3229-0503
Azhar IqbalDepartment of Restorative Dentistry, College of Dentistry, Jouf University, Sakaka 72345, Saudi Arabia.ORCID 0000-0002-4769-6653
Saad AlhumaidAdministration of Pharmaceutical Care, Al-Ahsa Health Cluster, Ministry of Health, Al-Ahsa 31982, Saudi Arabia.ORCID 0000-0003-4552-4513
Abbas Al MutairResearch Center, Almoosa Specialist Hospital, Al-Ahsa 36342, Saudi Arabia.
Ali A RabaanMolecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia.ORCID 0000-0002-6774-9847
Pietro MessinaDepartment of Surgical, Oncological and Stomatological Disciplines, University of Palermo, 90133 Palermo, Italy.
Giuseppe Alessandro ScardinaDepartment of Surgical, Oncological and Stomatological Disciplines, University of Palermo, 90133 Palermo, Italy.ORCID 0000-0001-7305-530X
Omdurman Islamic University · SDUniversity of Palermo · ITAlfaisal University · SAAl-Neelain University · SDBayero University Kano · NGJouf University · SAMinistry of Health · MMNajran University · SAPrincess Nourah bint Abdulrahman University · SAUniversity of Puthisastra · KH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibodies (Abs) are important immune mediators and powerful diagnostic markers in a wide range of infectious diseases. Understanding the humoral immunity or the development of effective antibodies against SARS-CoV-2 is a prerequisite for limiting disease burden in the community and aids in the development of new diagnostic, therapeutic, and vaccination options. Accordingly, the role of antiviral antibodies in the resistance to and diagnosis of SARS-CoV-2 infection was explored. Antibody testing showed the potential in adding important diagnostic value to the routine diagnosis and clinical management of COVID-19. They could also play a critical role in COVID-19 surveillance, allowing for a better understanding of the full scope of the disease. The development of several vaccines and the success of passive immunotherapy suggest that anti-SARS-CoV-2 antibodies have the potential to be used in the treatment and prevention of SARS-CoV-2 infection. In this review, we highlight the role of antibodies in the diagnosis of SARS-CoV-2 infection and provide an update on their protective roles in controlling SARS-CoV-2 infection as well as vaccine development.

Indexed as

antibodiesCOVID-19immunotherapySARS-CoV-2serodiagnostictestingvaccine

Identifiers

PMID36016233
PMCPMC9412318
OpenAlexW4292335889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.