Evidence map›Paper›PMID 36016185›Full record

ArticleVaccines2022

Psychological and Psychiatric Events Following Immunization with Five Different Vaccines against SARS-CoV-2.

Mario García-Alanis, Marisa Morales-Cárdenas, Liz Nicole Toapanta-Yanchapaxi, Erwin Chiquete, Isaac Núñez, Santa Elizabeth Ceballos-Liceaga, Guillermo Carbajal-Sandoval, Carla Toledo-Salinas, David Alejandro Mendoza-Hernández, Selma Cecilia Scheffler-Mendoza and 14 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 8 institutions in 2 countries.

Mario García-AlanisDepartment of Neurology and Psychiatry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.
Marisa Morales-CárdenasDepartment of Neurology and Psychiatry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.ORCID 0000-0002-2435-8387
Liz Nicole Toapanta-YanchapaxiDepartment of Neurology and Psychiatry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.ORCID 0000-0002-1218-1721
Erwin ChiqueteDepartment of Neurology and Psychiatry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.ORCID 0000-0002-1142-295X
Isaac NúñezDepartment of Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.ORCID 0000-0001-8859-9115
Santa Elizabeth Ceballos-LiceagaDirección General de Epidemiología, Secretaría de Salud, Mexico City 01480, Mexico.
Guillermo Carbajal-SandovalDirección General de Epidemiología, Secretaría de Salud, Mexico City 01480, Mexico.
Carla Toledo-SalinasComisión Coordinadora de Institutos Nacionales de Salud y Hospitales de Alta Especialidad, Mexico City 14610, Mexico.ORCID 0000-0002-9354-2479
David Alejandro Mendoza-HernándezInstituto Nacional de Pediatría, Mexico City 04530, Mexico.ORCID 0000-0002-6162-7136
Selma Cecilia Scheffler-MendozaInstituto Nacional de Pediatría, Mexico City 04530, Mexico.ORCID 0000-0001-6548-5721
José Antonio Ortega-MartellUniversidad Autónoma del Estado de Hidalgo, Pachuca 42039, Mexico.
Daniel Armando Carrillo-GarcíaDirección General de Epidemiología, Secretaría de Salud, Mexico City 01480, Mexico.
Noé Hernández-ValdiviaDirección General de Epidemiología, Secretaría de Salud, Mexico City 01480, Mexico.ORCID 0000-0002-7334-6366
Alonso Gutiérrez-RomeroDepartment of Neurology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City 14269, Mexico.
Javier Andrés Galnares-OlaldeDepartment of Neurology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City 14269, Mexico.
Fernando Daniel Flores-SilvaDepartment of Neurology and Psychiatry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.ORCID 0000-0002-3324-3565
José Luis Díaz-OrtegaCentro Nacional para la Salud de la Infancia y la Adolescencia, Secretaría de Salud, Mexico City 14080, Mexico.
Gustavo Reyes-TeránComisión Coordinadora de Institutos Nacionales de Salud y Hospitales de Alta Especialidad, Mexico City 14610, Mexico.
Hugo López-GatellSecretaría de Salud, Gobierno de México, Mexico City 01480, Mexico.
Ricardo Cortes-AlcaláSecretaría de Salud, Gobierno de México, Mexico City 01480, Mexico.
José Rogelio Pérez-PadillaInstituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.
Antonio ArauzDepartment of Neurology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City 14269, Mexico.ORCID 0000-0002-3340-4138
Miguel García-GrimshawDepartment of Neurology and Psychiatry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.ORCID 0000-0001-5287-1068
Sergio Iván Valdés-FerrerDepartment of Neurology and Psychiatry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.ORCID 0000-0002-4863-6484
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MXSecretaria de Salud · MXInstituto Nacional de Neurología y Neurocirugía · MXHospitales Regionales de Alta Especialidad · MXInstituto Nacional de Pediatria · MXFeinstein Institute for Medical Research · USInstituto Nacional de Enfermedades Respiratorias · MXUniversidad Autónoma del Estado de Hidalgo · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite the high number of vaccines administered against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) worldwide, the information on the psychological/psychiatric adverse events following immunization (AEFI) with these newly developed vaccines remains scarce.

objectiveTo describe the frequency of psychological/psychiatric symptoms among recipients of five different anti-SARS-CoV-2 vaccines and to explore the factors associated with their development reported in the nationwide Mexican registry of AEFI against SARS-CoV-2.

methodsDescriptive study of all the psychological/psychiatric symptoms, including anxiety, panic attacks, insomnia, and agitation reported to the Mexican Epidemiological Surveillance System from 21 December 2020 to 27 April 2021, among adult (≥18 years old) recipients of 7,812,845 doses of BNT162b2, ChAdOx1 nCov-19, rAd26-rAd5, Ad5-nCoV, or CoronaVac. The factors associated with their development are determined by multivariate regression analysis.

resultsThere were 19,163 AEFI reports during the study period; amongst them, 191 (1%) patients had psychological/psychiatric symptoms (median age of 41 years, interquartile range of 32-54; 149 [78%] women) for an observed incidence of 2.44 cases per 100,000 administered doses (95% confidence interval [CI] 2.12-2.82), 72.8% of psychiatric AEFIs were reported among recipients of BNT162b2. The median time from vaccination to symptom onset was 35 min (interquartile range: 10-720). Overall, the most common psychological/psychiatric symptoms were anxiety in 129 (67.5%) patients, panic attacks in 30 (15.7%), insomnia in 25 (13%), and agitation in 11 (5.7%). After adjusting for the confounding factors, the odds for developing psychological/psychiatric symptoms were higher for those concurrently reporting syncope (odds ratio [OR]: 4.73, 95% CI: 1.68-13.33); palpitations (OR: 2.47, 95% CI: 1.65-3.70), and dizziness (OR: 1.59, 95% CI: 1.10-2.28).

conclusionIn our population, psychological/psychiatric symptoms were extremely infrequent AEFIs. No severe psychiatric AEFIs were reported. Immunization stress-related responses might explain most of the detected cases.

Indexed as

anxietyfearimmunization stress-related responsespanic attackSARS-CoV-2vaccines

Identifiers

PMID36016185
PMCPMC9415094
OpenAlexW4291158523

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.