ArticleVaccines2022
SARS-CoV-2 Breakthrough Infections: Incidence and Risk Factors in a Large European Multicentric Cohort of Health Workers.
Abstract read
In one paragraph
Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Impact of Occupational and Extra-Professional Exposure Across the Different Waves of the Pandemic on the Risk of SARS-CoV-2 Infection Among Healthcare Workers-The ORCHESTRA Project.Healthcare (Basel, Switzerland) · 2026Article
- The role of hospitals in monitoring the emergency: the experience of "Sentinel network" of the Italian Federation of Health Trusts.BMC health services research · 2026Article
- Article
- Article
- [Status of COVID-19 vaccination among staff at the Tengandogo University Hospital Center, Ouagadougou, Burkina Faso, June to December 2021].Medecine tropicale et sante internationale · 2025Article
- COVID-19 Vaccination Uptake and Effectiveness for Hospitalized Cases Among Healthcare Workers in Tertiary Hospital.Vaccines · 2025Article
- Article
- Objectively measured peri-vaccination sleep does not predict COVID-19 breakthrough infection.Scientific reports · 2024Article
- Determinants of compliance to influenza and COVID-19 vaccination in a cohort of solid organ transplant patients in Puglia, Southern Italy (2017-2022).Human vaccines & immunotherapeutics · 2023Article
- SARS-CoV-2 Infections, Re-Infections and Clinical Characteristics: A Two-Year Retrospective Study in a Large University Hospital Cohort of Vaccinated Healthcare Workers.Journal of clinical medicine · 2023Article
- Incidence and Determinants of Symptomatic and Asymptomatic SARS-CoV-2 Breakthrough Infections After Booster Dose in a Large European Multicentric Cohort of Health Workers-ORCHESTRA Project.Journal of epidemiology and global health · 2023Article
- How European Research Projects Can Support Vaccination Strategies: The Case of the ORCHESTRA Project for SARS-CoV-2.Vaccines · 2023Article
- Article
- A retrospective cohort study of incidence and risk factors for severe SARS-CoV-2 breakthrough infection among fully vaccinated people.Scientific reports · 2023Article
- Severity and Outcome of Post-Vaccine COVID-19 among Healthcare Workers in a University Hospital in India.Journal of medicine and life · 2023Article
- Article
- An observational multi-centric COVID-19 sequelae study among health care workers.The Lancet regional health. Southeast Asia · 2023Article
- Estimation of the Effectiveness of a Tighter, Reinforced Quarantine for the Coronavirus Disease 2019 (COVID-19) Outbreak: Analysis of the Third Wave in South Korea.Journal of personalized medicine · 2023Article
- Incidence and Associated Factors of SARS-CoV-2 Infection Post-mRNA-1273 Booster Vaccination in Health-Care Workers.Vaccines · 2023Article
- Correlations between SARS-CoV-2 Infections and the Number of COVID-19 Vaccine Doses Administered in Three Italian Provinces.Healthcare (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
76 authors.
Stefano PorruSection of Occupational Medicine, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.
Maria Grazia Lourdes MonacoOccupational Medicine Unit, University Hospital of Verona, 37134 Verona, Italy.ORCID 0000-0003-4951-2528
Gianluca SpiteriOccupational Medicine Unit, University Hospital of Verona, 37134 Verona, Italy.ORCID 0000-0001-8536-7095
Angela CartaSection of Occupational Medicine, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-3620-8765
Maria Diletta PezzaniInfectious Diseases Unit, University Hospital of Verona, 37134 Verona, Italy.
Giuseppe LippiSection of Clinical Biochemistry, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.ORCID 0000-0001-9523-9054
Davide GibelliniSection of Microbiology, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.
Evelina TacconelliInfectious Diseases Unit, University Hospital of Verona, 37134 Verona, Italy.
Ilaria Dalla VecchiaSection of Infectious Diseases, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.
Emma SalaUnit of Occupational Health, Hygiene, Toxicology and Prevention, University Hospital ASST Spedali Civili, 25121 Brescia, Italy.ORCID 0000-0002-0882-6574
Emanuele SansoneUnit of Occupational Health and Industrial Hygiene, Department of Medical Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, 25121 Brescia, Italy.ORCID 0000-0002-1932-0800
Giuseppe De PalmaUnit of Occupational Health, Hygiene, Toxicology and Prevention, University Hospital ASST Spedali Civili, 25121 Brescia, Italy.ORCID 0000-0001-9821-3060
Carlo BonfantiDepartment of Molecular and Translational Medicine, Institute of Microbiology, University of Brescia-ASST Spedali Civili, 25121 Brescia, Italy.
Massimo LombardoChief Executive Office, ASST Spedali Civili di Brescia, 25121 Brescia, Italy.
Luigina TerlenghiDepartment of Molecular and Translational Medicine, Institute of Microbiology, University of Brescia-ASST Spedali Civili, 25121 Brescia, Italy.
Enrico PiraDepartment of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy.ORCID 0000-0003-2754-0827
Ihab MansourDepartment of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy.ORCID 0000-0003-4854-7622
Maurizio CoggiolaOccupational Medicine Unit, University Hospital Città Della Salute e Della Scienza di Torino, 10126 Turin, Italy.
Catalina CiocanDepartment of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy.
Alessandro GodonoDepartment of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy.ORCID 0000-0001-8095-5461
Adonina TardonHealth Research Institute of Asturias (ISPA), CIBERESP and Public Health Department of the University of Oviedo, Campus del Cristo s/n, 33006 Oviedo, Spain.ORCID 0000-0001-5150-1209
Marta-Maria Rodriguez-SuarezHealth Research Institute of Asturias (ISPA), CIBERESP and Public Health Department of the University of Oviedo, Campus del Cristo s/n, 33006 Oviedo, Spain.
Guillermo Fernandez-TardonHealth Research Institute of Asturias (ISPA), CIBERESP and Public Health Department of the University of Oviedo, Campus del Cristo s/n, 33006 Oviedo, Spain.ORCID 0000-0002-7680-158X
Francisco-Jose Jimeno-DemuthHealth Research Institute of Asturias (ISPA), CIBERESP and Public Health Department of the University of Oviedo, Campus del Cristo s/n, 33006 Oviedo, Spain.
Rafael-Vicente Castro-DelgadoHealth Research Institute of Asturias (ISPA), CIBERESP and Public Health Department of the University of Oviedo, Campus del Cristo s/n, 33006 Oviedo, Spain.
Tania Iglesias CaboHealth Research Institute of Asturias (ISPA), CIBERESP and Public Health Department of the University of Oviedo, Campus del Cristo s/n, 33006 Oviedo, Spain.ORCID 0000-0002-0208-4880
Maria Luisa ScapellatoDepartment of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.
Filippo LivieroDepartment of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.
Angelo MorettoDepartment of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.
Paola MasonDepartment of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.ORCID 0000-0003-3941-6698
Sofia PavanelloDepartment of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.ORCID 0000-0002-5229-9900
Anna VolpinUniversity Hospital of Padova, 35128 Padova, Italy.
Luigi VimercatiInterdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.ORCID 0000-0002-4072-2871
Silvio TafuriInterdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.ORCID 0000-0003-4194-0210
Luigi De MariaInterdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.ORCID 0000-0002-0553-5309
Stefania SponselliInterdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.
Pasquale StefanizziInterdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.
Antonio CaputiInterdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.ORCID 0000-0001-8872-6786
Fabriziomaria GobbaDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena & Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0002-1267-1632
Alberto ModeneseDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena & Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0002-0850-5615
Loretta CasolariHealth Surveillance Service, University Hospital of Modena, 41125 Modena, Italy.ORCID 0000-0001-6360-7449
Denise GaraviniHealth Surveillance Service, University Hospital of Modena, 41125 Modena, Italy.
Cristiana D'EliaHealth Surveillance Service, University Hospital of Modena, 41125 Modena, Italy.
Stefania MarianiHealth Surveillance Service, University Hospital of Modena, 41125 Modena, Italy.
Francesca Larese FilonUnit of Occupational Medicine, Department of Medical Science, University of Trieste, 34149 Trieste, Italy.ORCID 0000-0002-7717-0417
Luca CegolonUnit of Occupational Medicine, Department of Medical Science, University of Trieste, 34149 Trieste, Italy.ORCID 0000-0002-6285-7355
Corrado NegroUnit of Occupational Medicine, Department of Medical Science, University of Trieste, 34149 Trieste, Italy.
Federico RoncheseUnit of Occupational Medicine, Department of Medical Science, University of Trieste, 34149 Trieste, Italy.
Francesca RuiUnit of Occupational Medicine, Department of Medical Science, University of Trieste, 34149 Trieste, Italy.
Paola De MichieliUnit of Occupational Medicine, Department of Medical Science, University of Trieste, 34149 Trieste, Italy.
Nicola MurgiaSection of Occupational Medicine, Respiratory Diseases and Toxicology, Department of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy.
Marco Dell'OmoSection of Occupational Medicine, Respiratory Diseases and Toxicology, Department of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy.
Giacomo MuziSection of Occupational Medicine, Respiratory Diseases and Toxicology, Department of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy.
Tiziana FiordiSection of Occupational Medicine, Respiratory Diseases and Toxicology, Department of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy.
Angela GambelungheSection of Occupational Medicine, Respiratory Diseases and Toxicology, Department of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy.
Ilenia FollettiSection of Occupational Medicine, Respiratory Diseases and Toxicology, Department of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy.
Dana MatesNational Institute of Public Health, 050463 Bucharest, Romania.
Violeta Claudia CalotaNational Institute of Public Health, 050463 Bucharest, Romania.
Andra NeamtuNational Institute of Public Health, 050463 Bucharest, Romania.
Ovidiu PersecaNational Institute of Public Health, 050463 Bucharest, Romania.
Catalin Alexandru StaicuNational Institute of Public Health, 050463 Bucharest, Romania.
Angelica VoinoiuNational Institute of Public Health, 050463 Bucharest, Romania.
Eleonóra FabiánováOccupational Health Department, Regional Authority of Public Health, 97556 Banská Bystrica, Slovakia.
Jana BérešováEpidemiology Health Department, Regional Authority of Public Health, 97556 Banská Bystrica, Slovakia.
Zora Kľocová AdamčákováHealth Promotion Department, Regional Authority of Public Health, 97556 Banská Bystrica, Slovakia.ORCID 0000-0002-8191-2401
Roman NedelaHealth Informatics Department, Regional Authority of Public Health, 97556 Banská Bystrica, Slovakia.
Anna LesňákováInfectology Clinic, Central Military Hospital, 03426 Ružomberok, Slovakia.ORCID 0000-0002-2152-9507
Jana HolčíkováOccupational Medicine Clinic, University Hospital, 83105 Bratislava, Slovakia.
Paolo BoffettaDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0002-3811-2791
Mahsa AbediniDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.
Giorgia DitanoDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.
Shuffield Seyram AsafoDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0001-7531-669X
Giovanni VisciDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.
Francesco Saverio ViolanteDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0003-4084-2782
Carlotta ZunarelliDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.
Giuseppe VerlatoUnit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.ORCID 0000-0001-5262-8818
Funding
European Commission 101016167
Abstract
backgroundThe research aimed to investigate the incidence of SARS-CoV-2 breakthrough infections and their determinants in a large European cohort of more than 60,000 health workers.
methodsA multicentric retrospective cohort study, involving 12 European centers, was carried out within the ORCHESTRA project, collecting data up to 18 November 2021 on fully vaccinated health workers. The cumulative incidence of SARS-CoV-2 breakthrough infections was investigated with its association with occupational and social-demographic characteristics (age, sex, job title, previous SARS-CoV-2 infection, antibody titer levels, and time from the vaccination course completion).
resultsAmong 64,172 health workers from 12 European health centers, 797 breakthrough infections were observed (cumulative incidence of 1.2%). The primary analysis using individual data on 8 out of 12 centers showed that age and previous infection significantly modified breakthrough infection rates. In the meta-analysis of aggregated data from all centers, previous SARS-CoV-2 infection and the standardized antibody titer were inversely related to the risk of breakthrough infection (
conclusionThe inverse correlation of antibody titer with the risk of breakthrough infection supports the evidence that vaccination plays a primary role in infection prevention, especially in health workers. Cellular immunity, previous clinical conditions, and vaccination timing should be further investigated.
Indexed as
breakthrough infectionsCOVID-19health workersoccupational and socio-demographic determinantsSARS-CoV-2 vaccination
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.