ArticlePolymers2022
Electrospun Polycaprolactone (PCL) Degradation: An In Vitro and In Vivo Study.
Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
93 citing papers in PubMed, 249 citations in OpenAlex.
- Understanding Polycaprolactone Degradation: Molecular Mechanisms and Implications for Biomedical Device Design.Materials (Basel, Switzerland) · 2026Review
- Host Response Impairs Tissue Integration of a Fibrin Hydrogel Scaffold Containing Poly(ε-caprolactone) Nanofibers for Peripheral Nerve Repair.Biomimetics (Basel, Switzerland) · 2026Article
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- Challenges and prospects of polymeric biomaterials in immune engineering: A review.Journal of biomaterials applications · 2026Review
- Thickness-Tunable Bilayer PBAT Nanofibrous Scaffolds for Enhancing r-AdMSCs' Tenogenic Commitment in Supraspinatus Tendon Regeneration.Journal of functional biomaterials · 2026Article
- Role of polymeric nanocomposite for tissue engineering applications.RSC advances · 2026Review
- Multifunctional scaffold based on TiMaterials today. Bio · 2026Article
- PolyGraph - Flexible, Biocompatible & Electrically Optimized Graphene-Polymer Composites for Next-Generation Neural Interfaces.Advanced healthcare materials · 2026Article
- Apolipoprotein E knockout attenuates vascular graft fibrosis by reducing profibrotic macrophage formation through low-density lipoprotein receptor related protein 1.Bioactive materials · 2026Article
- Article
- Biodegradable synthetic polymers for biomedical and tissue engineering applications: tailoring degradation kinetics with tissue regeneration timeline.Biomedical engineering online · 2026Review
- Evaluation of a GDNF-eluting nanofibrous PCL conduit in a mouse model of peripheral nerve injury.RSC advances · 2026Article
- Hybrid SES-MEW Scaffold Strategies: A Narrative Review of Multi-Scale Fiber Architectures for Soft and Hard Tissue Engineering.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Synthetic-Polymer-Based Cardiac Patches for MI-Induced Heart Failure Treatment: A Review.Biomolecules · 2026Review
- Functional restoration of uterine architecture and fertility via a 3D-printed biomimetic scaffold: The role of macrophage-driven immunomodulation.Materials today. Bio · 2026Article
- Mechanical tunability of oriented and random electrospun poly(ε-caprolactone) scaffolds via concentration, molecular weight, and environment.Scientific reports · 2026Article
- Multi-functional self-powered nanofiber conduit for peripheral nerve regeneration and muscle atrophy prevention.Journal of nanobiotechnology · 2026Article
- Coaxial nanofiber design for traumatic brain injury: a review and framework for phase-responsive therapeutics.Discover nano · 2026Review
- Advanced delivery of natural bioactive compounds for atopic dermatitis: a review of polymeric conjugates and nanocarriers.Natural products and bioprospecting · 2026Review
- Fibrous Biomaterial Scaffold for Tympanic Membrane Repair: Microarchitectural Engineering and Structure Function Performance.Journal of functional biomaterials · 2026Review
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Polycaprolactone (PCL) is widely used in tissue engineering due to its interesting properties, namely biocompatibility, biodegradability, elastic nature, availability, cost efficacy, and the approval of health authorities such as the American Food and Drug Administration (FDA). The PCL degradation rate is not the most adequate for specific applications such as skin regeneration due to the hydrophobic nature of bulk PCL. However, PCL electrospun fiber meshes, due to their low diameters resulting in high surface area, are expected to exhibit a fast degradation rate. In this work, in vitro and in vivo degradation studies were performed over 90 days to evaluate the potential of electrospun PCL as a wound dressing. Enzymatic and hydrolytic degradation studies in vitro, performed in a static medium, demonstrated the influence of lipase, which promoted a rate of degradation of 97% for PCL meshes. In an in vivo scenario, the degradation was slower, although the samples were not rejected, and were well-integrated in the surrounding tissues inside the subcutaneous pockets specifically created.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.