Evidence map›Paper›PMID 36015528›Full record

ArticlePolymers2022

Cryostructuring of Polymeric Systems: 62 Preparation and Characterization of Alginate/Chondroitin Sulfate Cryostructurates Loaded with Antimicrobial Substances.

Olga I Vernaya, Andrey N Ryabev, Tatyana I Shabatina, Daria L Karlova, Andrey V Shabatin, Lyudmila N Bulatnikova, Alexander M Semenov, Mikhail Ya Melnikov, Vladimir I Lozinsky

Abstract read
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In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Olga I VernayaChemistry Department, M. V. Lomonosov Moscow State University, 119991 Moscow, Russia.
Andrey N RyabevA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilov Street 28, Bld. 1, 119334 Moscow, Russia.
Tatyana I ShabatinaChemistry Department, M. V. Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0001-8151-3016
Daria L KarlovaChemistry Department, M. V. Lomonosov Moscow State University, 119991 Moscow, Russia.
Andrey V ShabatinA. N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Leninsky Ave. 31, Bld. 4, 119071 Moscow, Russia.
Lyudmila N BulatnikovaA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilov Street 28, Bld. 1, 119334 Moscow, Russia.
Alexander M SemenovBiology Department, M. V. Lomonosov Moscow State University, 119991 Moscow, Russia.
Mikhail Ya MelnikovChemistry Department, M. V. Lomonosov Moscow State University, 119991 Moscow, Russia.
Vladimir I LozinskyA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilov Street 28, Bld. 1, 119334 Moscow, Russia.ORCID 0000-0002-8111-1161

Funding

Russian Scientific Foundation RSF - 22-63-000006
6 · The paper itself

Abstract

Targeted drug release is a significant research focus in the development of drug delivery systems and involves a biocompatible polymeric carrier and certain medicines. Cryostructuring is a suitable approach for the preparation of efficient macroporous carriers for such drug delivery systems. In the current study, the cryogenically structured carriers based on alginate/chondroitin sulfate mixtures were prepared and their physicochemical properties and their ability to absorb/release the bactericides were evaluated. The swelling parameters of the polysaccharide matrix, the amount of the tightly bound water in the polymer and the sulfur content were measured. In addition, FTIR and UV spectroscopy, optical and scanning microscopy, as well as a standard disk diffusion method for determining antibacterial activity were used. It was shown that alginate/chondroitin sulfate concentration and their ratios were significant factors influencing the swelling properties and the porosity of the resultant cryostructurates. It was demonstrated that the presence of chondroitin sulfate in the composition of a polymeric matrix slowed down the release of the aminoglycoside antibiotic gentamicin. In the case of the NH

Indexed as

alginatechondroitin sulfatecontrolled drug release systemscryostructuratesdioxidinegentamicin sulfate

Identifiers

PMID36015528
PMCPMC9414213

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.