Evidence map›Paper›PMID 36015346›Full record

ArticlePharmaceutics2022

Unequal Behaviour between Hydrolysable Functions of Nirmatrelvir under Stress Conditions: Structural and Theoretical Approaches in Support of Preformulation Studies.

Philippe-Henri Secretan, Maxime Annereau, Willy Kini-Matondo, Bastien Prost, Jade Prudhomme, Lina Bournane, Muriel Paul, Najet Yagoubi, Hassane Sadou-Yayé, Bernard Do

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Philippe-Henri SecretanMatériaux et Santé, Université Paris-Saclay, 92296 Châtenay-Malabry, France.ORCID 0000-0002-5838-3695
Maxime AnnereauMatériaux et Santé, Université Paris-Saclay, 92296 Châtenay-Malabry, France.ORCID 0000-0001-9594-2516
Willy Kini-MatondoDepartment of Pharmacy, Henri Mondor Hospital, AP-HP, 94010 Creteil, France.
Bastien ProstUMS-IPSIT-SAMM, Ingénierie et Plateformes au Service de l'Innovation Thérapeutique, Université Paris-Saclay, 92296 Châtenay-Malabry, France.
Jade PrudhommeMatériaux et Santé, Université Paris-Saclay, 92296 Châtenay-Malabry, France.
Lina BournaneMatériaux et Santé, Université Paris-Saclay, 92296 Châtenay-Malabry, France.
Muriel PaulDepartment of Pharmacy, Henri Mondor Hospital, AP-HP, 94010 Creteil, France.
Najet YagoubiMatériaux et Santé, Université Paris-Saclay, 92296 Châtenay-Malabry, France.
Hassane Sadou-YayéMatériaux et Santé, Université Paris-Saclay, 92296 Châtenay-Malabry, France.ORCID 0000-0002-7191-9423
Bernard DoMatériaux et Santé, Université Paris-Saclay, 92296 Châtenay-Malabry, France.ORCID 0000-0002-1131-2080
Université Paris-Saclay · FRAssistance Publique – Hôpitaux de Paris · FRUniversité Paris-Est Créteil · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nirmatrelvir is an antiviral drug approved for the treatment of COVID-19. The available dosage form consists of tablets marketed under the brand name PAXLOVID

Indexed as

ab initio calculationsdegradation productsDFTmass spectrometrypreformulation studiesselective hydrolysis

Identifiers

PMID36015346
PMCPMC9412384
OpenAlexW4293065091

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.