Evidence map›Paper›PMID 36015329›Full record

ReviewPharmaceutics2022

Herb Polysaccharide-Based Drug Delivery System: Fabrication, Properties, and Applications for Immunotherapy.

Yubiao Cao, Zhuowen Chen, Liangliang Sun, Yameng Lin, Ye Yang, Xiuming Cui, Chengxiao Wang

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Anticancer Mechanism ofPharmaceuticals (Basel, Switzerland) · 2024
    Review
  5. Review
  6. Preparation and in vitro Immunoreactivity ofIranian journal of pharmaceutical research : IJPR
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yubiao CaoSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
Zhuowen ChenSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
Liangliang SunSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
Yameng LinSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
Ye YangSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
Xiuming CuiSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
Chengxiao WangSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
Yunnan Metallurgical Group (China) · CNKunming University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herb polysaccharides (HPS) have been studied extensively for their healthcare applications. Though the toxicity was not fully clarified, HPS were widely accepted for their biodegradability and biocompatibility. In addition, as carbohydrate polymers with a unique chemical composition, molecular weight, and functional group profile, HPS can be conjugated, cross-linked, and functionally modified. Thus, they are great candidates for the fabrication of drug delivery systems (DDS). HPS-based DDS (HPS-DDS) can bypass phagocytosis by the reticuloendothelial system, prevent the degradation of biomolecules, and increase the bioavailability of small molecules, thus exerting therapeutic effects. In this review, we focus on the application of HPS as components of immunoregulatory DDS. We summarize the principles governing the fabrication of HPS-DDS, including nanoparticles, micelles, liposomes, microemulsions, hydrogels, and microneedles. In addition, we discuss the role of HPS in DDS for immunotherapy. This comprehensive review provides valuable insights that could guide the design of effective HPS-DDS.

Indexed as

applicationdrug delivery systemherb polysaccharidesimmune regulationstructure modification

Identifiers

PMID36015329
PMCPMC9414761
OpenAlexW4292183909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.