Evidence map›Paper›PMID 36015269›Full record

ArticlePharmaceutics2022

Glasdegib Dimaleate: Synthesis, Characterization and Comparison of Its Properties with Monomaleate Analogue.

Boris Peklar, Franc Perdih, Damjan Makuc, Janez Plavec, Jérôme Cluzeau, Zoran Kitanovski, Zdenko Časar

Abstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Boris PeklarLek Pharmaceuticals d.d., Sandoz Development Center Slovenia, Kolodvorska 27, 1234 Mengeš, Slovenia.
Franc PerdihFaculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, 1000 Ljubljana, Slovenia.ORCID 0000-0002-8416-7291
Damjan MakucSlovenian NMR Centre, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.
Janez PlavecSlovenian NMR Centre, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.ORCID 0000-0003-1570-8602
Jérôme CluzeauLek Pharmaceuticals d.d., Sandoz Development Center Slovenia, Kolodvorska 27, 1234 Mengeš, Slovenia.
Zoran KitanovskiLek Pharmaceuticals d.d., Sandoz Development Center Slovenia, Kolodvorska 27, 1234 Mengeš, Slovenia.ORCID 0000-0002-3205-0024
Zdenko ČasarLek Pharmaceuticals d.d., Sandoz Development Center Slovenia, Kolodvorska 27, 1234 Mengeš, Slovenia.ORCID 0000-0002-6689-3353

Funding

Lek Pharmaceuticals d.d.
6 · The paper itself

Abstract

Glasdegib is a recently approved drug for the treatment of acute myeloid leukemia. It is formulated and marketed in monomaleate salt form. In our investigation, we were able to prepare a glasdegib dimaleate form, which could, in theory, exist in double-salt form or as a mixture of salt and co-crystal species. Therefore, the obtained crystals of glasdegib dimaleate were characterized via

Indexed as

glasdegibsaltssolubilityssNMRstabilityX-ray diffraction

Identifiers

PMID36015269
PMCPMC9415664

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.