ArticlePharmaceutics2022
Fabrication and Preliminary In Vitro Evaluation of 3D-Printed Alginate Films with Cannabidiol (CBD) and Cannabigerol (CBG) Nanoparticles for Potential Wound-Healing Applications.
Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- 3D-Printed Mucoadhesive Hydrogel Buccal Films Based on HPMC and Carbopol Bioinks Incorporating Cyclodextrin-Cannabinoid Complexes and Terpenes.Gels (Basel, Switzerland) · 2026Article
- Cannabinoids for Dermatological Applications: Mechanistic Insights, Clinical Evidence, and Emerging Nanotechnology-Enabled Delivery Strategies.Pharmaceutics · 2026Review
- Cannabinoid Oral Mucosal Delivery: Approaches to Formulation, Fabrication, and Permeation Enhancement.AAPS PharmSciTech · 2026Review
- Development and Characterization of Dissolving Microneedles for the Buccal Delivery of Cannabidiol (CBD).Micromachines · 2026Article
- 3D-Printed Alginate-Chitosan Hydrogel Loaded with Cannabidiol as a Platform for Drug Delivery: Design and Mechanistic Characterization.Journal of functional biomaterials · 2025Article
- Potential Antimicrobial Use of Cannabidiol in Dentistry: A Scoping Review.Dentistry journal · 2025Review
- Cannabidiol in Skin Health: A Comprehensive Review of Topical Applications in Dermatology and Cosmetic Science.Biomolecules · 2025Review
- Review
- Self-Assembled Cannabigerol-Based Nanoparticles: Design, Synthesis, and Antiproliferative Activity.Pharmaceutics · 2025Article
- The Incorporation of CBD into Biodegradable DL-Lactide/Glycolide Copolymers Creates a Persistent Antibacterial Environment: An In Vitro Study onPharmaceutics · 2025Article
- Evaluation of the antibacterial activity and mechanism of cannabigerol against drug-resistant Streptococcus iniae in vitro.Archives of microbiology · 2025Article
- Design of Aerated Oleogel-Hydrogel Mixtures for 3D Printing of Personalized Cannabis Edibles.Gels (Basel, Switzerland) · 2024Article
- HarnessingPharmaceutics · 2024Review
- Bioactive Properties and In Vitro Digestive Release of Cannabidiol (CBD) from Tailored Composites Based on Carbon Materials.Pharmaceutics · 2024Article
- Production of Biopolymeric Microparticles to Improve Cannabigerol Bioavailability.Materials (Basel, Switzerland) · 2024Article
- Enhancing the porosity of chitosan sponges with CBD by adding antimicrobial violacein.Heliyon · 2024Article
- Biopolymeric Insulin Membranes for Antimicrobial, Antioxidant, and Wound Healing Applications.Pharmaceutics · 2024Article
- Studies on Loading Salicylic Acid in Xerogel Films of Crosslinked Hyaluronic Acid.Gels (Basel, Switzerland) · 2024Article
- Article
- Improving the water solubility of cannabidiol using a peptide carrier.Turkish journal of chemistry · 2024Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, drug carrier nanoparticles comprised of Pluronic-F127 and cannabidiol (CBD) or cannabigerol (CBG) were developed, and their wound healing action was studied. They were further incorporated in 3D printed films based on sodium alginate. The prepared films were characterized morphologically and physicochemically and used to evaluate the drug release profiles of the nanoparticles. Additional studies on their water loss rate, water retention capacity, and 3D-printing shape fidelity were performed. Nanoparticles were characterized physicochemically and for their drug loading performance. They were further assessed for their cytotoxicity (MTT Assay) and wound healing action (Cell Scratch Assay). The in vitro wound-healing study showed that the nanoparticles successfully enhanced wound healing in the first 6 h of application, but in the following 6 h they had an adverse effect. MTT assay studies revealed that in the first 24 h, a concentration of 0.1 mg/mL nanoparticles resulted in satisfactory cell viability, whereas CBG nanoparticles were safe even at 48 h. However, in higher concentrations and after a threshold of 24 h, the cell viability was significantly decreased. The results also presented mono-disperse nano-sized particles with diameters smaller than 200 nm with excellent release profiles and enhanced thermal stability. Their entrapment efficiency and drug loading properties were higher than 97%. The release profiles of the active pharmaceutical ingredients from the films revealed a complete release within 24 h. The fabricated 3D-printed films hold promise for wound healing applications; however, more studies are needed to further elucidate their mechanism of action.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.