Evidence map›Paper›PMID 36015255›Full record

ArticlePharmaceutics2022

Tailoring of Rosuvastatin Calcium and Atenolol Bilayer Tablets for the Management of Hyperlipidemia Associated with Hypertension: A Preclinical Study.

Mahmoud M A Elsayed, Moustafa O Aboelez, Mohamed S Mohamed, Reda A Mahmoud, Ahmed A El-Shenawy, Essam A Mahmoud, Ahmed A Al-Karmalawy, Eman Y Santali, Sameer Alshehri, Mahmoud Elkot Mostafa Elsadek and 2 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Mahmoud M A ElsayedDepartment of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt.ORCID 0000-0001-9547-2243
Moustafa O AboelezDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt.ORCID 0000-0002-9489-3545
Mohamed S MohamedDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al Azhar University, Assiut 71524, Egypt.ORCID 0000-0001-7262-7396
Reda A MahmoudDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al Azhar University, Assiut 71524, Egypt.
Ahmed A El-ShenawyDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al Azhar University, Assiut 71524, Egypt.ORCID 0000-0003-0875-1602
Essam A MahmoudDepartment of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt.ORCID 0000-0003-0662-5928
Ahmed A Al-KarmalawyDepartment of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta 34518, Egypt.ORCID 0000-0002-8173-6073
Eman Y SantaliDepartment of Pharmaceutical Chemistry, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0003-1567-6305
Sameer AlshehriDepartment of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0003-2119-867X
Mahmoud Elkot Mostafa ElsadekDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Merit University, Sohag 82755, Egypt.
Mohamed A El HamdDepartment of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra 11961, Saudi Arabia.ORCID 0000-0002-9774-0587
Abd El Hakim RamadanDepartment of Pharmaceutics, Faculty of Pharmacy, Port Said University, Port Said 42515, Egypt.ORCID 0000-0003-0812-0149
Al-Azhar University · EGSohag University · EGTaif University · SADamietta University · EGPort Said University · EGSouth Valley University · EGZagazig University · EG

Funding

Taif University TURSP-2020/330
6 · The paper itself

Abstract

Hyperlipidemia is still the leading cause of heart disease in patients with hypertension. The purpose of this study is to make rosuvastatin calcium (ROS) and atenolol (AT) bilayer tablets to treat coexisting dyslipidemia and hypertension with a single product. ROS was chosen for the immediate-release layer of the constructed tablets, whereas AT was chosen for the sustained-release layer. The solid dispersion of ROS with sorbitol (1:3

Indexed as

atenololbilayer tabletsfactorial designhyperlipidemiahypertensionpreclinical studiesrosuvastatin calcium

Identifiers

PMID36015255
PMCPMC9412892
OpenAlexW4289860609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.