Evidence map›Paper›PMID 36015179›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

Design, Synthesis and Biological Investigation of 2-Anilino Triazolopyrimidines as Tubulin Polymerization Inhibitors with Anticancer Activities.

Romeo Romagnoli, Paola Oliva, Filippo Prencipe, Stefano Manfredini, Federica Budassi, Andrea Brancale, Salvatore Ferla, Ernest Hamel, Diana Corallo, Sanja Aveic and 4 more

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Special Issue "Novel Anti-Proliferative Agents".Pharmaceuticals (Basel, Switzerland) · 2023
    Article
  6. Article
  7. 4-(Aryl)-Benzo[4,5]imidazo[1,2-Molecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Romeo RomagnoliDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-6374-773X
Paola OlivaDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44121 Ferrara, Italy.
Filippo PrencipeDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, 34127 Trieste, Italy.
Stefano ManfrediniDepartment of Life Sciences and Biotechnology, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-1348-4422
Federica BudassiMedicinal Chemistry Department, Integrated Drug Discovery, Aptuit-An Evotec Company, 37135 Verona, Italy.
Andrea BrancaleSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, UK.ORCID 0000-0002-9728-3419
Salvatore FerlaFaculty of Medicine, Health and Life Science, Swansea University Medical School, Grove Building, Swansea University, Swansea SA2 8PP, UK.ORCID 0000-0002-5918-9237
Ernest HamelMolecular Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, Frederick National Laboratory for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
Diana CoralloLaboratory of Target Discovery and Biology of Neuroblastoma, Istituto di Ricerca Pediatrica (IRP), Fondazione Città della Speranza, 35128 Padova, Italy.
Sanja AveicLaboratory of Target Discovery and Biology of Neuroblastoma, Istituto di Ricerca Pediatrica (IRP), Fondazione Città della Speranza, 35128 Padova, Italy.ORCID 0000-0002-3886-4360
Lorenzo ManfredaDepartment of Woman's and Child's Health, Hemato-Oncology Lab, University of Padova, 35131 Padova, Italy.
Elena MariottoDepartment of Woman's and Child's Health, Hemato-Oncology Lab, University of Padova, 35131 Padova, Italy.ORCID 0000-0002-3960-8561
Roberta BortolozziDepartment of Woman's and Child's Health, Hemato-Oncology Lab, University of Padova, 35131 Padova, Italy.ORCID 0000-0002-3357-4815
Giampietro ViolaDepartment of Woman's and Child's Health, Hemato-Oncology Lab, University of Padova, 35131 Padova, Italy.ORCID 0000-0001-9329-165X

Funding

CCR NIH HHS HHSN261200800001CMinistry of Education, Universities and Research 2017E84AA4_002NCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

A further investigation aiming to generate new potential antitumor agents led us to synthesize a new series of twenty-two compounds characterized by the presence of the 7-(3',4',5'-trimethoxyphenyl)-[1,2,4]triazolo[1,5-

Indexed as

[1,2,4]triazolo[1,5-a]pyrimidineantitumor activityapoptosiscolchicine binding sitemicrotubule-targeting agents

Identifiers

PMID36015179
PMCPMC9415608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.