Evidence map›Paper›PMID 36015158›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

A Study on Repositioning Nalidixic Acid via Lanthanide Complexation: Synthesis, Characterization, Cytotoxicity and DNA/Protein Binding Studies.

Ana-Madalina Maciuca, Alexandra-Cristina Munteanu, Mirela Mihaila, Mihaela Badea, Rodica Olar, George Mihai Nitulescu, Cristian V A Munteanu, Valentina Uivarosi

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ana-Madalina MaciucaDepartment of General and Inorganic Chemistry, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Str., 020956 Bucharest, Romania.
Alexandra-Cristina MunteanuDepartment of General and Inorganic Chemistry, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Str., 020956 Bucharest, Romania.
Mirela MihailaCenter of Immunology, Stefan S. Nicolau Institute of Virology, 285 Mihai Bravu Ave, 030304 Bucharest, Romania.ORCID 0000-0001-8302-8823
Mihaela BadeaDepartment of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., 050663 Bucharest, Romania.ORCID 0000-0002-4018-7610
Rodica OlarDepartment of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., 050663 Bucharest, Romania.ORCID 0000-0002-4208-0972
George Mihai NitulescuDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Str., 020956 Bucharest, Romania.ORCID 0000-0002-2978-8052
Cristian V A MunteanuRomanian Academy-Institute of Biochemistry (IBAR), 296 Splaiul. Independenţei, 060031 Bucharest, Romania.ORCID 0000-0002-2998-0458
Valentina UivarosiDepartment of General and Inorganic Chemistry, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Str., 020956 Bucharest, Romania.ORCID 0000-0002-7165-5069
Carol Davila University of Medicine and Pharmacy · ROUniversity of Bucharest · ROInstitute of Biochemistry · RO

Funding

Carol Davila University of Medicine and Pharmacy 33PFE/30.12.2021Ministerul Cercetării și Inovării 383PED/2020Ministerul Cercetării și Inovării PN-III-P1-1.1-PD-2019-1312Ministerul Cercetării și Inovării PN-III-P1-1.1-TE-2021-1660
6 · The paper itself

Abstract

"Drug repositioning" is a modern strategy used to uncover new applications for out-of-date drugs. In this context, nalidixic acid, the first member of the quinolone class with limited use today, has been selected to obtain nine new metal complexes with lanthanide cations (La

Indexed as

anticancerDNA bindingdrug repositioninglanthanide ionsnalidixic acidquinolonesserum proteins binding

Identifiers

PMID36015158
PMCPMC9412414
OpenAlexW4292259682

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.