Evidence map›Paper›PMID 36015135›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

Toxicity Profiles of Kleeb Bua Daeng Formula, a Traditional Thai Medicine, and Its Protective Effects on Memory Impairment in Animals.

Pornthip Waiwut, Kanchana Kengkoom, Wanassanun Pannangrong, Natdanai Musigavong, Chantha Chheng, Kusawadee Plekratoke, Pitchayakarn Taklomthong, Nutchareeporn Nillert, Supaporn Pitiporn, Pakakrong Kwankhao and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pornthip WaiwutFaculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand.
Kanchana KengkoomNational Laboratory Animal Centre, Mahidol University, Nakorn Pathom 73170, Thailand.
Wanassanun PannangrongDepartment of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0002-8820-5873
Natdanai MusigavongCenter of Evidence-Based Thai Traditional and Herbal Medicine, Chao Phya Abhaibhubejhr Hospital, Mueang Prachinburi 25000, Thailand.
Chantha ChhengFaculty of Pharmaceutical Sciences, Khon Kean University, Khon Kean 40002, Thailand.
Kusawadee PlekratokeFaculty of Pharmaceutical Sciences, Khon Kean University, Khon Kean 40002, Thailand.
Pitchayakarn TaklomthongFaculty of Pharmaceutical Sciences, Khon Kean University, Khon Kean 40002, Thailand.
Nutchareeporn NillertDepartment of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Supaporn PitipornCenter of Evidence-Based Thai Traditional and Herbal Medicine, Chao Phya Abhaibhubejhr Hospital, Mueang Prachinburi 25000, Thailand.
Pakakrong KwankhaoCenter of Evidence-Based Thai Traditional and Herbal Medicine, Chao Phya Abhaibhubejhr Hospital, Mueang Prachinburi 25000, Thailand.ORCID 0000-0001-6829-4349
Supawadee DaodeeFaculty of Pharmaceutical Sciences, Khon Kean University, Khon Kean 40002, Thailand.ORCID 0000-0003-2051-9953
Yaowared ChulikhitFaculty of Pharmaceutical Sciences, Khon Kean University, Khon Kean 40002, Thailand.
Orawan MontakantiratFaculty of Pharmaceutical Sciences, Khon Kean University, Khon Kean 40002, Thailand.
Chantana BoonyaratFaculty of Pharmaceutical Sciences, Khon Kean University, Khon Kean 40002, Thailand.ORCID 0000-0003-4065-6090

Funding

Chao Phya Abhaibhubejhr hospital foundationFaculty of Pharmaceutical Sciences, Khon Kaen University, ThailandKhon Kaen University I62-00-21-03Research Transfer Affairs, Khon Kaen University, ThailandThailand Research Fund DBG6080006The Royal Scholarship under Her Royal Highness Princess Maha Chakri Sirindhorn Education Project to the Kingdom of Cambodia
6 · The paper itself

Abstract

Kleeb Bua Daeng (KBD) formula has long been used in Thailand as a traditional herbal medicine for promoting brain health. Our recent reports illustrated that KBD demonstrates multiple modes of action against several targets in the pathological cascade of Alzheimer's disease (AD). The main purpose of the present study was to determine the protective effect and mechanism of KBD in amyloid beta (Aβ)-induced AD rats and its toxicity profiles. Pretreatment with the KBD formula for 14 days significantly improved the short- and long-term memory performance of Aβ-induced AD rats as assessed by the Morris Water Maze (MWM) and object-recognition tests. KBD treatment increased the activities of the antioxidant enzymes catalase, superoxide dismutase, and glutathione peroxidase; reduced the malondialdehyde content, and; decreased the acetylcholinesterase activity in the rat brain. An acute toxicity test revealed that the maximum dose of 2000 mg/kg did not cause any mortality or symptoms of toxicity. An oral, subchronic toxicity assessment of KBD at doses of 125, 250, and 500 mg/kg body weight/day for 90 days showed no adverse effects on behavior, mortality, hematology, or serum biochemistry. Our investigations indicate that KBD is a nontoxic traditional medicine with good potential for the prevention and treatment of AD.

Indexed as

acute toxicityamyloid beta-induced memory deficitCentella asiaticaNelumbo nuciferaPiper nigrumsub-chronic toxicitytraditional herbal medicine

Identifiers

PMID36015135
PMCPMC9414439

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.