Evidence map›Paper›PMID 36015068›Full record

ArticlePathogens (Basel, Switzerland)2022

Angiotensin-Converting Enzyme 2 SNPs as Common Genetic Loci and Optimal Early Identification Genetic Markers for COVID-19.

Yan Ma, Qiuyue Li, Jun Chen, Songmei Liu, Shanshan Liu, Xiaomeng He, Yun Ling, Jianghua Zheng, Christopher Corpe, Hongzhou Lu and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Yan MaShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Qiuyue LiShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Jun ChenShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Songmei LiuCenter for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Shanshan LiuShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Xiaomeng HeShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Yun LingShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Jianghua ZhengDepartment of Laboratory Medicine, Zhoupu Hospital Affiliated to Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.
Christopher CorpeNutritional Science Department, King's College London, 150 Stamford Street, Waterloo, London SE1 9NH, UK.ORCID 0000-0003-1994-8312
Hongzhou LuNational Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518112, China.
Jin WangShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.ORCID 0000-0002-0062-2489
Shanghai Public Health Clinical Center · CNWuhan University · CNKing's College London · GBShanghai University of Medicine and Health Sciences · CNSouthern University of Science and Technology · CN

Funding

National Natural Science Foundation of China 81672383National Special Research Program of China for Important Infectious Diseases 2018ZX10302103-003Science and Technology Commission of Shanghai Municipality 20Y11900700，20411950200，20Z11900900Special Research Fund of Youan Medical Alliance for the Liver and Infectious Diseases LM202020
6 · The paper itself

Abstract

Background: Angiotensin-converting enzyme 2 (ACE2) is implicated as a host cell receptor that causes infection in the pathogenesis of coronavirus disease 2019 (COVID-19), and its genetic polymorphisms in the ACE2 gene may promote cardiovascular disease and systemic inflammatory injury in COVID-19 patients. Hence, the genetic background may potentially explain the broad interindividual variation in disease susceptibility and/or severity. Methods: Genetic susceptibility to COVID-19 was analyzed by examining single-nucleotide polymorphisms (SNPs) of ACE2 in 246 patients with COVID-19 and 210 normal controls using the TaqMan genotyping assay. Results: We demonstrated that the ACE2 SNPs rs4646142, rs6632677, and rs2074192 were associated with COVID-19 (for all, p  <  0.05), and the differences in the ACE2 SNPs rs4646142 and rs6632677 were correlated with COVID-19-related systemic inflammatory injury and cardiovascular risk. Specifically, rs4646142 was associated with high-sensitivity C-reactive protein (hs-CRP), prealbumin (PAB), apolipoprotein A (APOA), high-density lipoprotein (HDL), and acid glycoprotein (AGP) levels. Rs6632677 was also associated with elevated CRP, acid glycoprotein (AGP), and haptoglobin (HPT). Conclusions: Our results suggest that the ACE2 SNPs rs4646142 and rs6632677 may be common genetic loci and optimal early identification genetic markers for COVID-19 with cardiovascular risk.

Indexed as

ACE2cardiovascular risksCOVID-19SNP

Identifiers

PMID36015068
PMCPMC9415427
OpenAlexW4292978060

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.