Evidence map›Paper›PMID 36015053›Full record

ArticlePathogens (Basel, Switzerland)2022

Localization of Epigenetic Markers in

Jacquelyn R McDonald, Bryan C Jensen, Aakash Sur, Iris L K Wong, Stephen M Beverley, Peter J Myler

Open access · goldAbstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jacquelyn R McDonaldCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
Bryan C JensenCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
Aakash SurDepartment of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA 98195, USA.
Iris L K WongDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Stephen M BeverleyDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-5319-0811
Peter J MylerCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.ORCID 0000-0002-0056-0513
Infectious Disease Research Institute · USWashington University in St. Louis · USUniversity of Washington Medical Center · US

Funding

MOLECULAR GENETICS OF LEISHMANIA USING DNA TRANSFECTIONR01AI029646 · NIAID · WASHINGTON UNIVERSITY · PI BEVERLEY, STEPHEN M · 1990 to 2015
$9.3M
Base J and transcription termination in LeishmaniaR01AI103858 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI MYLER, PETER JOHN · 2013 to 2017
$2.8M
de novo creation of base J in LeishmaniaR21AI159041 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI JENSEN, BRYAN C · 2021 to 2022
$518k
NIAID NIH HHS R21 AI159041NIH HHS R01AI103858NIH HHS R21AI159041NIH HHS RO1AI29646
6 · The paper itself

Abstract

Eukaryotes use histone variants and post-translation modifications (PTMs), as well as DNA base modifications, to regulate DNA replication/repair, chromosome condensation, and gene expression. Despite the unusual organization of their protein-coding genes into large polycistronic transcription units (PTUs), trypanosomatid parasites also employ a "histone code" to control these processes, but the details of this epigenetic code are poorly understood. Here, we present the results of experiments designed to elucidate the distribution of histone variants and PTMs over the chromatin landscape of

Indexed as

epigenomehistone variantsLeishmaniapost translation modifications

Identifiers

PMID36015053
PMCPMC9413968
OpenAlexW4293778595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.