Evidence map›Paper›PMID 36014861›Full record

ArticleNutrients2022

Levels of Vitamin D and Expression of the Vitamin D Receptor in Relation to Breast Cancer Risk and Survival.

Linnea Huss, Salma Tunå Butt, Signe Borgquist, Karin Elebro, Malte Sandsveden, Jonas Manjer, Ann Rosendahl

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Linnea HussDepartment of Surgery, Helsingborg Hospital, 251 87 Helsingborg, Sweden.ORCID 0000-0002-8597-9224
Salma Tunå ButtDepartment of Clinical Sciences, Lund University, 221 00 Lund, Sweden.
Signe BorgquistDepartment of Clinical Sciences, Division of Oncology and Pathology, Lund University, Skåne University Hospital, 221 00 Lund, Sweden.
Karin ElebroDepartment of Clinical Sciences, Lund University, 221 00 Lund, Sweden.
Malte SandsvedenDepartment of Clinical Sciences, Lund University, 221 00 Lund, Sweden.ORCID 0000-0002-4630-5075
Jonas ManjerDepartment of Clinical Sciences, Lund University, 221 00 Lund, Sweden.
Ann RosendahlDepartment of Clinical Sciences, Division of Oncology and Pathology, Lund University, Skåne University Hospital, 221 00 Lund, Sweden.ORCID 0000-0003-0066-0677
Lund University · SE

Funding

Gunnar Nilsson Cancer Foundation UnknownMalmö University Hospital Cancer Research Fund UnknownRegion Skåne (ALF) UnknownSkåne University Hospital UnknownSwedish Cancer Society unknownThe Einar and Inga Nilsson Foundation UnknownThe Henning and Ida Persson Foundation unknown
6 · The paper itself

Abstract

Previous research suggests associations between low systemic levels of vitamin D and poor breast cancer prognosis and between expression of the vitamin D receptor (VDR) in breast cancers and survival. This study aimed to study associations between pre-diagnostic systemic levels of vitamin D and expression of VDR in subsequent breast tumors, and interactions between vitamin D and VDR on breast cancer mortality. Systemic vitamin D levels were measured in women within the Malmö Diet and Cancer Study. The expression of VDR was evaluated immunohistochemically in a tissue microarray of subsequent breast cancers. Statistical analyses followed. Women with high levels of vitamin D had a smaller proportion of VDR negative breast tumors compared to women with low levels of vitamin D (odds ratio: 0.68; 95% confidence interval: 0.41-1.13). Vitamin D levels were not found to modify the association between low VDR expression and high breast cancer mortality. To conclude, there was no statistical evidence for an association between pre-diagnostic levels of vitamin D and the expression of VDRs in breast cancer, nor did vitamin D levels influence the association between VDR expression and breast cancer mortality. Further studies are needed in order to establish the effects of vitamin D on breast cancer.

Indexed as

Breast NeoplasmsReceptors, CalcitriolVitamin DFemaleHumansRiskVitaminsReceptors, CalcitriolVitamin DVitaminsbreast cancerincidencesurvivalvitamin Dvitamin D receptor

Identifiers

PMID36014861
PMCPMC9414444
OpenAlexW4292259018

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.