Trial reportNutrients2022
Effect of a Multi-Strain Probiotic on the Incidence and Severity of Necrotizing Enterocolitis and Feeding Intolerances in Preterm Neonates.
Trial report in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Pooled it
- Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants.The Cochrane database of systematic reviews · 2023Pooled it
- Probiotics for the prevention of mortality and sepsis in preterm very low birth weight neonates from low- and middle-income countries: a Bayesian network meta-analysis.Frontiers in nutrition · 2023Pooled it
- Effect of a Multi-Strain Probiotic on Growth and Time to Reach Full Feeds in Preterm Neonates.Nutrients · 2022Trial
- Relationship between gut microbiota establishment patterns and the risk of necrotizing enterocolitis in preterm infants: a retrospective cohort study.Translational pediatrics · 2026Article
- Synergistic regulation of gut microbiota and metabolites by breast milk and probiotics in the prevention of neonatal necrotizing enterocolitis: mechanisms and prospects.Translational pediatrics · 2026Review
- Multi-strain Probiotics for Treatment of Necrotizing Enterocolitis in Preterm Rats: Histological and Immunohistochemical Evaluation.Probiotics and antimicrobial proteins · 2026Article
- Early supplementation with live combinedFrontiers in cellular and infection microbiology · 2026Observational
- Gestational constipation and the gut microbiota: mechanisms, interventions, and implications for maternal and offspring health.Frontiers in nutrition · 2026Review
- The microbiome's hidden influence: preclinical insights into inflammatory responses in necrotizing enterocolitis.Seminars in immunopathology · 2025Review
- Necrotizing Enterocolitis: What's New and What's Next?International journal of molecular sciences · 2025Review
- An early post-birth immune-microbiota landscape predicts the development of necrotizing enterocolitis in term newborns with congenital heart defects.Scientific reports · 2025Article
- Microbiota-Modulating Strategies in Neonates Undergoing Surgery for Congenital Gastrointestinal Conditions: A Narrative Review.Nutrients · 2025Review
- High-potency multi-strain probiotic formulations for safety and improvement of gastrointestinal function and intestinal health: a randomized controlled clinical trial.Frontiers in nutrition · 2025Article
- Shaping oral and intestinal microbiota and the immune system during the first 1,000 days of life.Frontiers in pediatrics · 2025Review
- Use of Dietary Supplements among Polish Children with Inflammatory Bowel Disease: A Two-Center Pilot Study.Nutrients · 2024Article
- Contemporary use of prophylactic probiotics in NICUs in the United States: a survey update.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Article
- Risk factors of necrotizing enterocolitis in twin preterm infants.BMC pediatrics · 2024Article
- A Mini Literature Review of Probiotics: Transforming Gastrointestinal Health Through Evidence-Based Insights.Cureus · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
Background: Necrotizing enterocolitis (NEC) is a multifactorial disease, causing inflammation of the bowel. The exact root of NEC is still unknown, but a low weight and gestational age at birth are known causes. Furthermore, antibiotic use and abnormal bacterial colonization of the premature gut are possible causes. Premature neonates often experience feeding intolerances that disrupts the nutritional intake, leading to poor growth and neurodevelopmental impairment. Methods: We conducted a double-blind, placebo-controlled, randomized clinical trial to investigate the effect of a multi-strain probiotic formulation (LabinicTM) on the incidence and severity of NEC and feeding intolerances in preterm neonates. Results: There were five neonates in the placebo group who developed NEC (Stage 1A−3B), compared to no neonates in the probiotic group. Further, the use of probiotics showed a statistically significant reduction in the development of feeding intolerances, p < 0.001. Conclusion: A multi-strain probiotic is a safe and cost-effective way of preventing NEC and feeding intolerances in premature neonates.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.