Evidence map›Paper›PMID 36014781›Full record

ArticleNutrients2022

Pregnancy and COVID-19: The Possible Contribution of Vitamin D.

Alessandra Manca, Stefano Cosma, Alice Palermiti, Martina Costanzo, Miriam Antonucci, Elisa Delia De Vivo, Alice Ianniello, Fulvio Borella, Andrea Roberto Carosso, Silvia Corcione and 4 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Alessandra MancaLaboratory of Clinical Pharmacology and Pharmacogenetics, Department of Medical Sciences, University of Turin, Amedeo di Savoia Hospital, 10149 Turin, Italy.ORCID 0000-0002-8540-6709
Stefano CosmaObstetrics and Gynecology Unit 1, Department of Surgical Sciences, Sant'Anna Hospital, University of Turin, 10126 Turin, Italy.ORCID 0000-0003-0563-0071
Alice PalermitiLaboratory of Clinical Pharmacology and Pharmacogenetics, Department of Medical Sciences, University of Turin, Amedeo di Savoia Hospital, 10149 Turin, Italy.ORCID 0000-0003-0860-280X
Martina CostanzoLaboratory of Clinical Pharmacology and Pharmacogenetics, Department of Medical Sciences, University of Turin, Amedeo di Savoia Hospital, 10149 Turin, Italy.
Miriam AntonucciASL Città di Torino, Amedeo di Savoia Hospital, 10149 Turin, Italy.
Elisa Delia De VivoLaboratory of Clinical Pharmacology and Pharmacogenetics, Department of Medical Sciences, University of Turin, Amedeo di Savoia Hospital, 10149 Turin, Italy.ORCID 0000-0003-4826-7604
Alice IannielloLaboratory of Clinical Pharmacology and Pharmacogenetics, Department of Medical Sciences, University of Turin, Amedeo di Savoia Hospital, 10149 Turin, Italy.
Fulvio BorellaObstetrics and Gynecology Unit 1, Department of Surgical Sciences, Sant'Anna Hospital, University of Turin, 10126 Turin, Italy.ORCID 0000-0001-8398-7557
Andrea Roberto CarossoObstetrics and Gynecology Unit 1, Department of Surgical Sciences, Sant'Anna Hospital, University of Turin, 10126 Turin, Italy.ORCID 0000-0002-7734-4499
Silvia CorcioneUnit of Infectious Diseases, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza, 10126 Turin, Italy.
Francesco Giuseppe De RosaUnit of Infectious Diseases, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza, 10126 Turin, Italy.ORCID 0000-0001-8338-0130
Chiara BenedettoObstetrics and Gynecology Unit 1, Department of Surgical Sciences, Sant'Anna Hospital, University of Turin, 10126 Turin, Italy.
Antonio D'AvolioLaboratory of Clinical Pharmacology and Pharmacogenetics, Department of Medical Sciences, University of Turin, Amedeo di Savoia Hospital, 10149 Turin, Italy.ORCID 0000-0002-1321-4126
Jessica CusatoLaboratory of Clinical Pharmacology and Pharmacogenetics, Department of Medical Sciences, University of Turin, Amedeo di Savoia Hospital, 10149 Turin, Italy.ORCID 0000-0003-1977-9694
Ospedale Amedeo di Savoia · ITOspedale Sant'Anna · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D deficiency has been associated with the severity of COVID-19. The role of vitamin D in pregnant women with COVID-19 has been poorly investigated to date. The aim of this study was to evaluate the influence of vitamin D in affecting some clinical features in pregnancy between SARS-CoV-2 positive and negative patients.

methodsVitamin D pathway related polymorphisms and 25-hydroxyvitamin D levels were quantified in pregnant women followed from the first to the third trimester of pregnancy. Vitamin D deficiency was considered with values ≤ 30 ng/mL.

resultsIn total, 160 women were enrolled: 23 resulted positive for at least one SARS-CoV-2 related test (molecular swab or antibody tests). Vitamin D-associated polymorphisms were able to affect vitamin D levels in SARS-CoV-2 negative and positive subjects: remarkably, all the

conclusionsThis is the first study demonstrating a role of vitamin D in affecting the clinical characteristics of pregnant women during the COVID-19 era. Further studies in larger and different cohorts of patients are required to confirm these findings.

Indexed as

COVID-19PregnancyPremature BirthVitamin DVitamin D DeficiencyFemaleHumansInfant, NewbornSARS-CoV-2Vitamin Dbiomarkersgenetic polymorphismsnewbornSARS-CoV-2VDRvitamin D

Identifiers

PMID36014781
PMCPMC9414046
OpenAlexW4291017205

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.