Evidence map›Paper›PMID 36014560›Full record

ArticleMolecules (Basel, Switzerland)2022

SARS-CoV-2 and MERS-CoV Spike Protein Binding Studies Support Stable Mimic of Bound 9-

Lisa Oh, Ajit Varki, Xi Chen, Lee-Ping Wang

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Sialosides Containing 7-ACS infectious diseases · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Lisa OhDepartment of Chemistry, University of California, Davis, CA 95616, USA.ORCID 0000-0001-8572-9738
Ajit VarkiGlycobiology Research and Training Center, Departments of Medicine and Cellular and Molecular Medicine, University of California, San Diego, CA 92093, USA.
Xi ChenDepartment of Chemistry, University of California, Davis, CA 95616, USA.ORCID 0000-0002-3160-614X
Lee-Ping WangDepartment of Chemistry, University of California, Davis, CA 95616, USA.
University of California, Davis · USUniversity of California San Diego · US

Funding

BIOSYNTHESIS AND REGULATION OF SUBSTITUTED SIALIC ACIDSR01GM032373 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VARKI, AJIT P · 1985 to 2022
$6.9M
Supplement: Exploring the biology of O-acetyl sialic acids using stable synthetic mimicsR01AI130684 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XI, VARKI, AJIT P · 2017 to 2020
$2.3M
NIAID NIH HHS R01 AI130684NIGMS NIH HHS R01 GM032373NIH HHS R01AI130684
6 · The paper itself

Abstract

Many disease-causing viruses target sialic acids (Sias), a class of nine-carbon sugars known to coat the surface of many cells, including those in the lungs. Human beta coronaviridae, known for causing respiratory tract diseases, often bind Sias, and some preferentially bind to those with 9-

Indexed as

COVID-19Middle East Respiratory Syndrome CoronavirusBinding SitesHumansPandemicsProtein BindingReceptors, VirusSARS-CoV-2Sialic AcidsSpike Glycoprotein, CoronavirusReceptors, VirusSialic AcidsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2binding free energy simulationsCoV S proteinMERS-CoVMM-PBSAmolecular dynamicsSARS-CoV-2sialic acidSOMD

Identifiers

PMID36014560
PMCPMC9415320
OpenAlexW4292566461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.