Evidence map›Paper›PMID 36014553›Full record

ReviewMolecules (Basel, Switzerland)2022

Rhamnose-Containing Compounds: Biosynthesis and Applications.

Siqiang Li, Fujia Chen, Yun Li, Lizhen Wang, Hongyan Li, Guofeng Gu, Enzhong Li

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Dysregulation of a nucleotidyltransferase induces division and surface glycan defects inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Rhamnose biosynthesis is not impaired by the deletion of putativeApplied and environmental microbiology · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Comparative analysis ofFrontiers in microbiology · 2025
    Article
  13. Review
  14. O26 Polysaccharides as Key Players in EnteropathogenicInternational journal of molecular sciences · 2024
    Article
  15. Review
  16. Article
  17. Frontiers in microbiology · 2024
    Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Siqiang LiSchool of Biological and Food Processing Engineering, Huanghuai University, Zhumadian 463000, China.ORCID 0000-0003-4184-7972
Fujia ChenSchool of Biological and Food Processing Engineering, Huanghuai University, Zhumadian 463000, China.
Yun LiSchool of Biological and Food Processing Engineering, Huanghuai University, Zhumadian 463000, China.
Lizhen WangBiology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250100, China.ORCID 0000-0003-4743-6939
Hongyan LiSchool of Biological and Food Processing Engineering, Huanghuai University, Zhumadian 463000, China.
Guofeng GuNational Glycoengineering Research Center, Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, 72 Binhai Road, Qingdao 266237, China.ORCID 0000-0002-0969-7487
Enzhong LiSchool of Biological and Food Processing Engineering, Huanghuai University, Zhumadian 463000, China.

Funding

the Key Science and Technology Innovation Demonstration Projects of Henan Province 191110110600the Natural Science Foundation of Henan Province 212300410203, 202300410279the Scientific and Technological Research Project Foundation of Henan Provincial Sci-entific and Technological Department 202102310479, 222102110180
6 · The paper itself

Abstract

Rhamnose-associated molecules are attracting attention because they are present in bacteria but not mammals, making them potentially useful as antibacterial agents. Additionally, they are also valuable for tumor immunotherapy. Thus, studies on the functions and biosynthetic pathways of rhamnose-containing compounds are in progress. In this paper, studies on the biosynthetic pathways of three rhamnose donors, i.e., deoxythymidinediphosphate-L-rhamnose (dTDP-Rha), uridine diphosphate-rhamnose (UDP-Rha), and guanosine diphosphate rhamnose (GDP-Rha), are firstly reviewed, together with the functions and crystal structures of those associated enzymes. Among them, dTDP-Rha is the most common rhamnose donor, and four enzymes, including glucose-1-phosphate thymidylyltransferase RmlA, dTDP-Glc-4,6-dehydratase RmlB, dTDP-4-keto-6-deoxy-Glc-3,5-epimerase RmlC, and dTDP-4-keto-Rha reductase RmlD, are involved in its biosynthesis. Secondly, several known rhamnosyltransferases from

Indexed as

Biosynthetic PathwaysRhamnoseRacemases and EpimerasesThymine NucleotidesUridine DiphosphateRacemases and EpimerasesRhamnoseThymine NucleotidesUridine Diphosphatedeoxythymidinediphosphate-L-rhamnoseguanosine diphosphate rhamnoserhamnoserhamnose biosynthesisrhamnosyltransferaseuridine diphosphate-rhamnose

Identifiers

PMID36014553
PMCPMC9415975

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.