Evidence map›Paper›PMID 36014474›Full record

ReviewMolecules (Basel, Switzerland)2022

Curcumin-Based Nanoformulations: A Promising Adjuvant towards Cancer Treatment.

Salar Hafez Ghoran, Andrea Calcaterra, Milad Abbasi, Fatemeh Taktaz, Kay Nieselt, Esmaeil Babaei

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06359665 (A Randomized Controlled Trial of Oral Curcumin for the Treatment of Pain of CMC Arthritis), which is not on this map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
8.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06359665 phase1enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

A Randomized Controlled Trial of Oral Curcumin for the Treatment of Pain of CMC Arthritis

TypeinterventionalSponsorBrent DeGeorgeRan2025 to 2026Enrolled100ConditionsArthritis of Carpometacarpal Joint of Left Thumb, Arthritis of Carpometacarpal Joint of Right ThumbArmsCurcumin, Placebo
3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Therapeutic Potential of Plant Phenolic Acids Combating Cancer Drug Resistance.Recent advances in food, nutrition & agriculture · 2026
    Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 3 countries.

Salar Hafez GhoranPhytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 16666-63111, Iran.ORCID 0000-0001-5495-5556
Andrea CalcaterraDepartment of Chemistry and Technology of Drugs, Sapienza-University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0001-7036-6620
Milad AbbasiDepartment of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz 71336-54361, Iran.
Fatemeh TaktazDepartment of Biology, Faculty of Sciences, University of Hakim Sabzevari, Sabzevar 96179-76487, Iran.ORCID 0000-0002-6521-4478
Kay NieseltInterfaculty Institute for Bioinformatics and Medical Informatics (IBMI), University of Tübingen, 72076 Tübingen, Germany.
Esmaeil BabaeiInterfaculty Institute for Bioinformatics and Medical Informatics (IBMI), University of Tübingen, 72076 Tübingen, Germany.ORCID 0000-0002-1603-5166
Sapienza University of Rome · ITShiraz University of Medical Sciences · IRUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Kurdistan · IRUniversity of Tabriz · IRUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Throughout the United States, cancer remains the second leading cause of death. Traditional treatments induce significant medical toxic effects and unpleasant adverse reactions, making them inappropriate for long-term use. Consequently, anticancer-drug resistance and relapse are frequent in certain situations. Thus, there is an urgent necessity to find effective antitumor medications that are specific and have few adverse consequences. Curcumin is a polyphenol derivative found in the turmeric plant (

Indexed as

Antineoplastic AgentsCurcuminNanoparticlesNeoplasmsAdjuvants, ImmunologicAdjuvants, PharmaceuticBiological AvailabilityHumansAdjuvants, ImmunologicAdjuvants, PharmaceuticAntineoplastic AgentsCurcumincancer immunotherapycancer treatmentcurcumin nanoformulationsdrug delivery systemnanocarriersnanocurcumin

Identifiers

PMID36014474
PMCPMC9414608
OpenAlexW4292253255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.