Evidence map›Paper›PMID 36014324›Full record

ArticleMolecules (Basel, Switzerland)2022

Isoquinoline Antimicrobial Agent: Activity against Intracellular Bacteria and Effect on Global Bacterial Proteome.

Caroline W Karanja, Nimishetti Naganna, Nader S Abutaleb, Neetu Dayal, Kenneth I Onyedibe, Uma Aryal, Mohamed N Seleem, Herman O Sintim

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Caroline W KaranjaDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA.
Nimishetti NagannaDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA.ORCID 0000-0002-6444-9398
Nader S AbutalebDepartment of Comparative Pathobiology, Purdue University College of Veterinary Medicine, 625 Harrison Street, West Lafayette, IN 47907, USA.
Neetu DayalDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA.
Kenneth I OnyedibeDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA.ORCID 0000-0001-8574-9747
Uma AryalDepartment of Comparative Pathobiology, Purdue University College of Veterinary Medicine, 625 Harrison Street, West Lafayette, IN 47907, USA.ORCID 0000-0003-4543-1536
Mohamed N SeleemDepartment of Comparative Pathobiology, Purdue University College of Veterinary Medicine, 625 Harrison Street, West Lafayette, IN 47907, USA.
Herman O SintimDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA.
Purdue University West Lafayette · US

Funding

Repurposing auranofin and ebselen for treatment of multidrug resistant pathogensR01AI130186 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SELEEM, MOHAMED · 2017 to 2021
$2.3M
NIAID NIH HHS R01 AI130186NIH HHS R01AI130186
6 · The paper itself

Abstract

A new class of alkynyl isoquinoline antibacterial compounds, synthesized via Sonogashira coupling, with strong bactericidal activity against a plethora of Gram-positive bacteria including methicillin- and vancomycin-resistant

Indexed as

Anti-Infective AgentsMethicillin-Resistant Staphylococcus aureusAnti-Bacterial AgentsBacteriaIsoquinolinesMicrobial Sensitivity TestsProteomeStaphylococcus aureusAnti-Bacterial AgentsAnti-Infective AgentsIsoquinolinesProteomeallkynyl isoquinoliesantimicrobial resistanceintracellular clearanceSonogashira coupling

Identifiers

PMID36014324
PMCPMC9416421
OpenAlexW4293780028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.