Evidence map›Paper›PMID 36014311›Full record

ArticleMolecules (Basel, Switzerland)2022

Novel Isoxazole Derivative Attenuates Ethanol-Induced Gastric Mucosal Injury through Inhibition of H

Sidra Razzaq, Amber Mahmood Minhas, Neelum Gul Qazi, Humaira Nadeem, Arif-Ullah Khan, Fawad Ali, Syed Shams Ul Hassan, Simona Bungau

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Pharmacological investigations of newly synthesized oxazolones and imidazolones as COX-2 inhibitors.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
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  9. Pharmacological Basis ofMolecules (Basel, Switzerland) · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Sidra RazzaqDepartment of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 46000, Pakistan.ORCID 0000-0001-9728-5265
Amber Mahmood MinhasDepartment of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 46000, Pakistan.
Neelum Gul QaziDepartment of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 46000, Pakistan.
Humaira NadeemDepartment of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 46000, Pakistan.
Arif-Ullah KhanDepartment of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 46000, Pakistan.ORCID 0000-0002-9627-2726
Fawad AliDepartment of Pharmacy, Kohat University of Science and Technology, Kohat 26000, Pakistan.ORCID 0000-0001-7667-5336
Syed Shams Ul HassanShanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0001-5188-6540
Simona BungauDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania.ORCID 0000-0003-3236-1292
Riphah International University · PKKohat University of Science and Technology · PKShanghai Jiao Tong University · CNUniversity of Oradea · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Isoxazole derivatives are significant enough due to their wide range of pharmacological and therapeutic activities. The purpose of the current study is to use computational, in vitro, in vivo, and extensive molecular approaches to examine the possible anti-ulcer activity of 4-benzylidene-3 methyl-1,2-isoxazol-5(4H)-one (MBO). Biovia Discovery Studio visualizer (DSV) was utilized for virtual screening. A tissue antioxidant investigation, H

Indexed as

Anti-Ulcer AgentsHelicobacter pyloriStomach UlcerAnimalsAntioxidantsEthanolGastric MucosaGlutathioneH(+)-K(+)-Exchanging ATPaseIsoxazolesOxidative StressPlant ExtractsProteomicsRatsAntioxidantsAnti-Ulcer AgentsEthanolGlutathioneH(+)-K(+)-Exchanging ATPaseIsoxazolesPlant Extractsanti-inflammatoryantioxidantgastric ulcerH+/K+-ATPase inhibitionin-silicoisoxazole

Identifiers

PMID36014311
PMCPMC9415046
OpenAlexW4293679825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.