Evidence map›Paper›PMID 36013786›Full record

ArticleMaterials (Basel, Switzerland)2022

Role of Natural Cross Linkers in Resin-Dentin Bond Durability: A Systematic Review and Meta-Analysis.

Lavanya Anumula, Sindhu Ramesh, Venkata Suneel Kumar Kolaparthi, Richard Kirubakaran, Mohmed Isaqali Karobari, Suraj Arora, Ahmed A Saleh, Omir Aldowah, Pietro Messina, Giuseppe Alessandro Scardina

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06780527 (Clinical Performance and Radiographic Assessment of Resin Composite Restoration After Dentin Biomodification by Grape Seed Extract in Vital Teeth With Deep Occlusal Carious Lesions. "18-M Randomized Clinical Trial"), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06780527 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Clinical Performance and Radiographic Assessment of Resin Composite Restoration After Dentin Biomodification by Grape Seed Extract in Vital Teeth With Deep Occlusal Carious Lesions. "18-M Randomized Clinical Trial"

TypeinterventionalSponsorCairo UniversityRan2025 to 2027Enrolled60ConditionsDeep Carious LesionsArms15% Grape seed extract as dentin pretreatment
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lavanya AnumulaDepartment of Conservative Dentistry and Endodontics, Narayana Dental College and Hospital, Nellore 524003, Andra Pradesh, India.
Sindhu RameshDepartment of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospital, Chennai 600077, Tamil Nadu, India.
Venkata Suneel Kumar KolaparthiDepartment of Oral Medicine and Radiology, Narayana Dental College and Hospital, Nellore 524003, Andra Pradesh, India.
Richard KirubakaranCochrane South Asia, BV Moses Centre for Evidence Informed Health Care and Health Policy, Christian Medical College, Vellore 632004, Tamil Nadu, India.
Mohmed Isaqali KarobariDepartment of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospital, Chennai 600077, Tamil Nadu, India.ORCID 0000-0002-0313-9695
Suraj AroraDepartment of Restorative Dental Sciences, King Khalid University, P.O. Box 960, Abha 61421, Saudi Arabia.
Ahmed A SalehDepartment of Restorative Dental Sciences, King Khalid University, P.O. Box 960, Abha 61421, Saudi Arabia.
Omir AldowahProsthetic Dental Science Department, Faculty of Dentistry, Najran University, Najran 11001, Saudi Arabia.ORCID 0000-0002-0121-7872
Pietro MessinaDepartment of Surgical, Oncological and Stomatological Disciplines, University of Palermo, 90133 Palermo, Italy.
Giuseppe Alessandro ScardinaDepartment of Surgical, Oncological and Stomatological Disciplines, University of Palermo, 90133 Palermo, Italy.ORCID 0000-0001-7305-530X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of endogenous Matrix Metallo Proteinases in resin dentin bond deterioration over time has been well documented. The present study aimed to systematically review the literature; in vitro and ex vivo studies that assessed the outcomes of natural cross-linkers for immediate and long-term tensile bond strength were included.

methodsThe manuscript search was carried out in six electronic databases-PubMed/MEDLINE, LILACS, SciELO, Cochrane, Web of Science and DOAJ, without publication year limits. Only manuscripts in English (including the translated articles) were selected, and the last search was performed in December 2020. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was followed.

resultsFrom the 128 potentially eligible studies, 48 full-text articles were assessed for eligibility. After eligibility assessment and exclusions, 14 studies were considered for systematic review and seven studies for meta-analysis. Amongst the selected studies for meta-analysis, three had a medium and four had a low risk of bias.

conclusionsIt was evidenced by the available data that Proanthocyanidin is the most efficient natural cross-linker to date, in preserving the bond strength even after ageing.

Indexed as

flavonoidsGrape seed extractmatrix metalloproteinasematrix metalloproteinase inhibitorsplant extract

Identifiers

PMID36013786
PMCPMC9413318

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.