ReviewMedicina (Kaunas, Lithuania)2022
Pathophysiological Aspects of Aging in Venous Thromboembolism: An Update.
Review in Medicina (Kaunas, Lithuania), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 46 citations in OpenAlex.
- Comparison of the Safety and Effectiveness of Apixaban Versus Rivaroxaban in Acute Venous Thromboembolism: A Propensity-Matched Real-World TriNetX Study with Obesity and Cancer Subgroup Analyses.Journal of clinical medicine · 2026Article
- Rising prevalence of venous thromboembolism in gastrointestinal cancers: a nationwide analysis of 205 million hospitalizations, 2016-2022.Journal of gastrointestinal oncology · 2026Article
- Development, internal testing, and external validation of an interpretable machine-learning model for predicting imaging-confirmed in-hospital postoperative deep vein thrombosis in older patients with patellar fractures.BMC medical informatics and decision making · 2026Article
- Temporal Trends and Future Projections of P ulmonary Embolism and Top Contributing Causes of death in the United States, 1968-2040: insights from the CDC WONDER database.Journal of thrombosis and thrombolysis · 2026Article
- Safety of upadacitinib in atopic dermatitis in randomized clinical trials across 6 years.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026Article
- Coagulation and Blood Factors and Clinical Disease Indicators in Patients with Chronic Angioedema and Urticaria-A Validation Study.Biomedicines · 2026Article
- Single-Cell Profiling Reveals RAB13Aging cell · 2026Article
- Clinical Profile and Admission Outcomes of Patients With Acute Pulmonary Embolism at a Resource-Constrained Hospital in Ghana: A Retrospective Pilot Study.Health science reports · 2026Article
- DETECT-VTE: an audit of patients with venous thromboembolism and their characteristics in general practice in the United Kingdom.Research and practice in thrombosis and haemostasis · 2026Article
- Metabolic syndrome and venous thromboembolism: the role of abdominal obesity and sex differences.Journal of thrombosis and thrombolysis · 2026Article
- Risk stratification of in-hospital venous thromboembolism for urological cancers: a multicenter retrospective study.Therapeutic advances in medical oncology · 2026Article
- Prevalence and risk factors of deep vein thrombosis in elderly: a systematic review and meta-analysis.Open medicine (Warsaw, Poland) · 2026Article
- Risk prediction model for thrombosis in leukemia patients: a systematic review.Frontiers in oncology · 2026Review
- Prothrombin conversion accelerates with increasing age in women but not in men: findings from the Moli-sani Cohort Study.Research and practice in thrombosis and haemostasis · 2026Article
- Article
- Preoperative deep vein thrombosis in tibial plateau fractures: development and internal validation of an interpretable multivariable machine-learning diagnostic model.Frontiers in medicine · 2026Article
- Impact of cardiovascular-kidney-metabolic syndrome staging on clinical outcomes and management of acute pulmonary embolism: A comprehensive analysis.International journal of cardiology. Heart & vasculature · 2025Article
- A nomogram for individualized prediction of calf muscular venous thrombosis in patients with acute ischemic stroke: a retrospective study.Thrombosis journal · 2025Article
- Article
- Silent Threats After Surgery: Incidence and Predictors of Deep Vein Thrombosis and Pulmonary Embolism in Orthopedic Patients.Diagnostics (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this review is to highlight all the factors that associate venous thromboembolism (VTE) with aging. Elderly people are characterized by a higher incidence of thrombosis taking into account the co-existing comorbidities, complications and fatality that arise. Based on the Virchow triad, pathophysiological aspects of venous stasis, endothelium injury and hypercoagulability in elderly people (≥65 years) are described in detail. More precisely, venous wall structure, nitric oxide (NO) and endothelin-1 expression are impaired in this age group. Furthermore, an increase in high-molecular-weight kininogen (HMWK), prekallikrein, factors V, VII, VIII, IX and XI, clot lysis time (CLT) and von Willebrand factor (vWF) is observed. Age-dependent platelet dysfunction and changes in anticoagulant factors are also illustrated. A "low-grade inflammation stage" is delineated as a possible risk factor for thrombosis in the elderly. Consequently, clinical implications for frail elderly people related to diagnosis, treatment, bleeding danger and VTE recurrence emerge. We conclude that aging is an acquired thrombotic factor closely related to pathophysiological changes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.