Trial reportMedicina (Kaunas, Lithuania)2022
Comparing the Efficacy of Intra-Articular Single Platelet-Rich Plasma(PRP) versus Novel Crosslinked Hyaluronic Acid for Early-Stage Knee Osteoarthritis: A Prospective, Double-Blind, Randomized Controlled Trial.
Open access · goldAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Medicina (Kaunas, Lithuania), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 7 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 7 pooled it
8.2field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 7 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Assessment of adverse events and safety associated with intra-articular platelet-rich plasma injections compared to other injectates for knee osteoarthritis: A systematic review and meta-analysis.PM & R : the journal of injury, function, and rehabilitation · 2026Pooled it
- Autologous platelet-rich plasma versus hyaluronic acid, corticosteroids or saline for knee osteoarthritis: can blood draw volume serve as a proxy for platelet dose? A systematic review and meta-analysis.International orthopaedics · 2026Pooled it
- Efficacy and safety of platelet-rich plasma injections for the treatment of knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.European journal of medical research · 2025Pooled it
- Intra-articular Hyaluronic Acid Injections May Be Beneficial in Patients with Less Advanced Knee Osteoarthritis: A Systematic Review of Randomised Controlled Trials.Sports medicine (Auckland, N.Z.) · 2025Pooled it
- Randomized Controlled Trials Studying Nonoperative Treatments of Osteoarthritis Often Use Misleading and Uninformative Control Groups: A Systematic Review.Clinical orthopaedics and related research · 2025Pooled it
- Comparison of hyaluronic acid and platelet-rich plasma in knee osteoarthritis: a systematic review.BMC musculoskeletal disorders · 2025Pooled it
- Effects of externally-applied, non-pharmacological Interventions on short- and long-term symptoms and inflammatory cytokine levels in patients with knee osteoarthritis: a systematic review and network meta-analysis.Frontiers in immunology · 2023Pooled it
- Influence of platelet-rich plasma composition on pain and functional performance in knee osteoarthritis: a systematic review and network meta-analysis.Knee surgery & related research · 2026Review
- Advances in hyaluronic acid therapy for knee osteoarthritis: monotherapy and combination strategies: an evidenced based review.Orthopedic reviews · 2026Article
- Impact of Symptomatic Slow-Acting Drugs on Inflammatory Pathways in Osteoarthritis: Therapeutic Advances and Future Challenges.ACS pharmacology & translational science · 2025Review
- Platelet rich plasma compared to viscosupplementation in the treatment of knee osteoarthritis: A systematic review and meta-analysis of randomised controlled trials with 6 month and 12 month follow-up.Journal of experimental orthopaedics · 2025Review
- Platelet-Rich Plasma for Knee Osteoarthritis: A Comprehensive Narrative Review of the Mechanisms, Preparation Protocols, and Clinical Evidence.Journal of clinical medicine · 2025Review
- Advancements in Regenerative Therapies for Orthopedics: A Comprehensive Review of Platelet-Rich Plasma, Mesenchymal Stem Cells, Peptide Therapies, and Biomimetic Applications.Journal of clinical medicine · 2025Review
- Comparison of Different Molecular Weights of Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis: A Level I Bayesian Network Meta-Analysis.Biomedicines · 2025Review
- Micro-needle knife combined with intra-articular and subchondral bone injection of platelet-rich plasma benefits moderate to advanced knee osteoarthritis.American journal of translational research · 2025Article
- Comparative analysis of single-dose platelet-rich plasma and hyaluronic acid therapies in knee osteoarthritis: A 12-week follow-up study.Northern clinics of Istanbul · 2025Article
- Platelet-rich plasma improves pain and function in knee osteoarthritis: a retrospective study.Frontiers in physiology · 2025Article
- Optimal Dosage of Platelet-Rich Plasma Injections in Patients With Osteoarthritis of the Knee: A Scoping Review.Cureus · 2024Review
- The Effect of Platelet Dose on Outcomes after Platelet Rich Plasma Injections for Musculoskeletal Conditions: A Systematic Review and Meta-Analysis.Current reviews in musculoskeletal medicine · 2024Review
- Randomized Controlled Trials for Platelet-Rich Plasma Use in Knee Osteoarthritis Rarely Report Key Sociodemographic Patient Variables: A Scoping Review.Arthroscopy, sports medicine, and rehabilitation · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Ying-Chun WangPh.D. Program in Biomedical Engineering, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Chia-Ling LeeDepartment of Physical Medicine and Rehabilitation, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Yu-Jen ChenDepartment of Radiology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.ORCID 0000-0002-4893-0800
Yin-Chun TienDepartment of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Sung-Yen LinDepartment of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Chung-Hwan ChenDepartment of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.ORCID 0000-0001-8941-4792
Paul Pei-Hsi ChouDepartment of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Hsuan-Ti HuangDepartment of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.ORCID 0000-0002-8638-1021
Kaohsiung Medical University · TW
Funding
Kaohsiung Municipal Hsiao-Kang Hospital KMHK-107-012Kaohsiung Municipal Ta-Tung Hospital KMTTH-108-005The Ministry of Health and Welfare of Taiwan MOHW106-TDU-B-212-113006The Ministry of Science and Technology of Taiwan MOST 106-2314-B-037-089-
Abstract
PubMed holds no abstract for this paper.
Indexed as
Osteoarthritis, KneePlatelet-Rich PlasmaHumansHyaluronic AcidInjections, Intra-ArticularPain MeasurementProspective StudiesTreatment OutcomeHyaluronic Acidcartilagegrowth factorhyaluronic acidosteoarthritisplatelet-rich plasma
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.