Evidence map›Paper›PMID 36013115›Full record

ReviewJournal of clinical medicine2022

Immunoglobulin Disorders and the Oral Cavity: A Narrative Review.

Maja Ptasiewicz, Dominika Bębnowska, Paulina Małkowska, Olga Sierawska, Agata Poniewierska-Baran, Rafał Hrynkiewicz, Paulina Niedźwiedzka-Rystwej, Ewelina Grywalska, Renata Chałas

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. The Role of Interleukin 6 in Periodontitis and Its Complications.International journal of molecular sciences · 2024
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Maja PtasiewiczDepartment of Oral Medicine, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0002-2156-5698
Dominika BębnowskaInstitute of Biology, University of Szczecin, 71-412 Szczecin, Poland.ORCID 0000-0003-3689-2381
Paulina MałkowskaInstitute of Biology, University of Szczecin, 71-412 Szczecin, Poland.ORCID 0000-0003-2430-5020
Olga SierawskaInstitute of Biology, University of Szczecin, 71-412 Szczecin, Poland.ORCID 0000-0003-3567-7786
Agata Poniewierska-BaranInstitute of Biology, University of Szczecin, 71-412 Szczecin, Poland.ORCID 0000-0001-6719-803X
Rafał HrynkiewiczInstitute of Biology, University of Szczecin, 71-412 Szczecin, Poland.ORCID 0000-0002-0688-6928
Paulina Niedźwiedzka-RystwejInstitute of Biology, University of Szczecin, 71-412 Szczecin, Poland.ORCID 0000-0003-4065-3842
Ewelina GrywalskaDepartment of Experimental Immunology, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0002-0451-4741
Renata ChałasDepartment of Oral Medicine, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0002-1730-4540
University of Szczecin · PLMedical University of Lublin · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The oral mucosa is a mechanical barrier against the penetration and colonization of microorganisms. Oral homeostasis is maintained by congenital and adaptive systems in conjunction with normal oral flora and an intact oral mucosa. Components contributing to the defense of the oral cavity include the salivary glands, innate antimicrobial proteins of saliva, plasma proteins, circulating white blood cells, keratinocyte products of the oral mucosa, and gingival crevicular fluid. General disturbances in the level of immunoglobulins in the human body may be manifested as pathological lesions in the oral mucosa. Symptoms of immunoglobulin-related general diseases such as mucous membrane pemphigoid (MMP), pemphigus vulgaris (PV), linear IgA bullous dermatosis (LABD), Epidermolysis Bullosa Aquisita (EBA), and Hyper-IgE syndrome (HIES) may appear in the oral cavity. In this review, authors present selected diseases associated with immunoglobulins in which the lesions appear in the oral cavity. Early detection and treatment of autoimmune diseases, sometimes showing a severe evolution (e.g., PV), allow the control of their dissemination and involvement of skin or other body organs. Immunoglobulin disorders with oral manifestations are not common, but knowledge, differentiation and diagnosis are essential for proper treatment.

Indexed as

Epidermolysis Bullosa Aquisita (EBA)Hyper-IgE Syndrome (HIES)immunoglobulinslinear IgA bullous dermatosis (LABD)mucous membrane pemphigoid (MMP)oral mucosapemphigus vulgaris (PV)

Identifiers

PMID36013115
PMCPMC9409910
OpenAlexW4292567344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.