Evidence map›Paper›PMID 36012989›Full record

ArticleJournal of clinical medicine2022

The Impact of Chronic Kidney Disease on Mid-Term Outcomes after Revascularisation of Peripheral Arterial Occlusive Disease: Results from a Prospective Cohort Study.

Artur Kotov, Deven A Blasche, Frederik Peters, Philip Pospiech, Ulrich Rother, Konstantinos Stavroulakis, Jürgen Remig, Christian Schmidt-Lauber, Thomas Zeller, Hartmut Görtz and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03098290 (IDOMENEO), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03098290 completednot on this map

IDOMENEO: Multimethodical and Multistage Registry-based Longitudinal Study Project to Collect Primary Registry Data and Health Insurance Claims Data of Patients Invasively Treated for Peripheral Artery Disease (PAD) in Germany

Typeobservational_patient_registrySponsorUniversitätsklinikum Hamburg-EppendorfRan2018 to 2021Enrolled5,608ConditionsSymptomatic Peripheral Arterial Disease, Occlusive Disease of Artery of Lower Extremity, Quality of LifeArmsCatheter-based endovascular revascularization, Bypass-Surgery, Endarterectomy
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Artur KotovResearch Group GermanVasc, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.
Deven A BlascheResearch Group GermanVasc, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.
Frederik PetersResearch Group GermanVasc, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0001-5832-8410
Philip PospiechResearch Group GermanVasc, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0001-8642-301X
Ulrich RotherDepartment of Vascular Surgery, University Medical Centre Erlangen, 91054 Erlangen, Germany.
Konstantinos StavroulakisCommission on Peripheral Artery Disease and Diabetic Foot Syndrome, German Society for Vascular Surgery and Vascular Medicine, 10115 Berlin, Germany.
Jürgen RemigBonn Community Hospital, Haus St. Petrus, 53113 Bonn, Germany.
Christian Schmidt-LauberIII. Department of Medicine, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.
Thomas ZellerClinic for Cardiology and Angiology II, University Heart Center Freiburg-Bad Krozingen, 79189 Bad Krozingen, Germany.ORCID 0000-0003-2704-3871
Hartmut GörtzCommission on Peripheral Artery Disease and Diabetic Foot Syndrome, German Society for Vascular Surgery and Vascular Medicine, 10115 Berlin, Germany.
Jörg TeßarekSt. Boniface Hospital Lingen, 49808 Lingen, Germany.
Christian-Alexander BehrendtResearch Group GermanVasc, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0003-0406-3319

Funding

German Federal Joint Committee 01VSF16008German Federal Joint Committee 01VSF18035
6 · The paper itself

Abstract

objectiveThe current study aimed to determine the relationship between chronic kidney disease (CKD) and major 12-month outcomes for patients with in-hospital treatment for symptomatic peripheral arterial occlusive disease (PAOD).

methodsAn analysis of the prospective longitudinal multicentric cohort study with 12-month follow-up was conducted including patients who underwent endovascular or open surgery for symptomatic PAOD at 35 German vascular centres (initial study protocol: NCT03098290). Severity of CKD was grouped into four stages combining information about the estimated glomerular filtration rate (eGFR) at baseline and dialysis dependency. Outcomes included overall mortality as well as the two composite endpoints of amputation or death, and of major cardiovascular events (MACE). 12-month incidences and adjusted hazard ratios were estimated using the Kaplan-Meier function and Cox proportional hazard models.

resultsA total of 4354 patients (32% female, 69 years mean age, 68% intermittent claudication, 69% percutaneous endovascular revascularisation) were included and followed for 244 days in median. Thereof, 22% had any CKD and 5% had end stage kidney disease (ESKD) at baseline. The 12-month overall mortality rate was 3.6% (95% CI 2.3-4.9) with 96 events in the entire cohort: 147 were amputated or died (5.3%, 95% CI 5.2-5.3), and 277 had a MACE (9.5%, 95% CI 9.4-9.5). When compared with patients without kidney disease, ESKD was significantly associated with overall mortality (HR 1.9; 95% CI 1.1-3.5), amputation or death (HR 2.4; 95% CI 1.4-4.1), and MACE (HR 2.0; 95% CI 1.3-3.2).

conclusionsIn the current study on mid-term outcomes after invasive revascularisation for symptomatic PAOD, one out of five patients suffered from any CKD while those few with ESKD had twice the odds of death, of amputation or death, and of major adverse cardiovascular events after twelve months. These results emphasise that concomitant CKD and its impact on outcomes should be considered by severity while mild and moderate grades should not lead to ineffectual treatment strategies.

Indexed as

chronic kidney diseasechronic limb-threatening ischaemiaend-stage kidney diseaseintermittent claudicationlower extremity artery diseaseopen and endovascular revascularisation

Identifiers

PMID36012989
PMCPMC9409847

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.