ArticleJournal of clinical medicine2022
Multivalvular Endocarditis: A Rare Condition with Poor Prognosis.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Multivalvular vs single-valve infective endocarditis: a systematic review and meta-analysis.Future cardiology · 2025Pooled it
- Article
- Multivalvular infective endocarditis due toOxford medical case reports · 2025Article
- Surgical and Clinical Aspects Associated with Double-Valve Infective Endocarditis.Journal of clinical medicine · 2025Article
- Bilateral valvular involvement in infective endocarditis: A clinically distinct entity? A multicenter retrospective study.PloS one · 2025Article
- Article
- Infective Endocarditis-Predictors of In-Hospital Mortality, 17 Years, Single-Center Experience in Bulgaria.Microorganisms · 2024Article
- Clinical profile, microbiology and outcomes in infective endocarditis treated with aortic valve replacement: a multicenter case-control study.BMC infectious diseases · 2024Article
- Infective Endocarditis-Characteristics and Prognosis According to the Affected Valves.Microorganisms · 2024Article
- Article
- One Fell Swoop: Septic Muscle Embolism and Central Venous Catheter Infection Imaged with [Diagnostics (Basel, Switzerland) · 2024Article
- Unraveling a rare presentation of bivalvular infective endocarditis using POCUS.Clinical case reports · 2023Article
- Is Infectious Endocarditis Evolving into a Time-Dependent Diagnosis in the Contemporary Epidemiological Era? Emphasis on the Role of Echocardiography as a First-Line Diagnostic Approach.Reviews in cardiovascular medicine · 2023Review
- Epidemiology, Diagnosis, Treatment, and Prognosis of Infective Endocarditis.Journal of clinical medicine · 2023Article
- Native and Prosthetic Simultaneously Double Valve Infective Endocarditis withJournal of personalized medicine · 2023Review
- A Multidisciplinary Approach toJournal of investigative medicine high impact case reportsArticle
Corrections and comments
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Authors and funding
16 authors at 11 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Infective endocarditis (IE) is a severe condition. Our aim was to describe the profile and prognosis of patients with multivalvular infective endocarditis (MIE) and compare them to single-valve IE (SIE). Methods. We used a retrospective analysis of the Spanish IE Registry (2008−2020). Results. From 4064 definite cases of valvular IE, 577 (14.2%) had MIE. In patients with MIE, the most common locations were mitral (552, 95.7%) and aortic (550, 95.3%), with mitral-aortic involvement present in 507 patients (87.9%). The most common etiologies were S. viridans (192, 33.3%) and S. aureus (113, 19.6%). MIE involved only native valves in 450 patients (78.0%). Compared with patients with SIE, patients with MIE had a similar age (69 vs. 67 years, respectively, p = 0.27) and similar baseline characteristics, but were more frequently men (67.1% vs. 72.9%, p = 0.005) and had a higher incidence of intracardiac complications (36.2% vs. 50.4%, p < 0.001), heart failure (42.7% vs. 52.9%, p < 0.001), surgical indication (67.7 vs. 85.1%, p < 0.001), surgery (46.3% vs. 56.3%), and in-hospital mortality (26.9% vs. 34.3%, p < 0.001). MIE was an independent predictor of in-hospital mortality (odds ratio (OR) 1.3, 95% confidence interval (CI) 1.1−1.7, p = 0.004) but did not have an independent association with 1-year mortality (OR 1.1, 95% CI 0.9−1.4, p = 0.43). Conclusions. About one-seventh of the valvular IE patients had MIE, mainly due to mitral-aortic involvement. MIE is associated with a poor in-hospital prognosis. An early diagnosis and treatment of IE might avoid its spread to a second valve.
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