Evidence map›Paper›PMID 36012752›Full record

ArticleInternational journal of molecular sciences2022

Blockade of Platelet Glycoprotein Ibα Augments Neuroprotection in Orai2-Deficient Mice during Middle Cerebral Artery Occlusion.

Michael Bieber, Michael K Schuhmann, Maximilian Bellut, David Stegner, Katrin G Heinze, Mirko Pham, Bernhard Nieswandt, Guido Stoll

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Michael BieberDepartment of Neurology, University Hospital Wuerzburg, 97080 Wuerzburg, Germany.ORCID 0000-0002-5535-6480
Michael K SchuhmannDepartment of Neurology, University Hospital Wuerzburg, 97080 Wuerzburg, Germany.
Maximilian BellutDepartment of Neurology, University Hospital Wuerzburg, 97080 Wuerzburg, Germany.ORCID 0000-0002-6462-9495
David StegnerRudolf Virchow Center for Integrative and Translational Bioimaging, University of Wuerzburg, 97080 Wuerzburg, Germany.ORCID 0000-0003-1059-9865
Katrin G HeinzeRudolf Virchow Center for Integrative and Translational Bioimaging, University of Wuerzburg, 97080 Wuerzburg, Germany.ORCID 0000-0003-2372-6800
Mirko PhamDepartment of Neuroradiology, University Hospital Wuerzburg, 97080 Wuerzburg, Germany.
Bernhard NieswandtRudolf Virchow Center for Integrative and Translational Bioimaging, University of Wuerzburg, 97080 Wuerzburg, Germany.
Guido StollDepartment of Neurology, University Hospital Wuerzburg, 97080 Wuerzburg, Germany.ORCID 0000-0003-2474-5165
Universitätsklinikum Würzburg · DEUniversity of Würzburg · DE

Funding

Deutsche Forschungsgemeinschaft 374031971 - TR240
6 · The paper itself

Abstract

During ischemic stroke, infarct growth before recanalization diminishes functional outcome. Hence, adjunct treatment options to protect the ischemic penumbra before recanalization are eagerly awaited. In experimental stroke targeting two different pathways conferred protection from penumbral tissue loss: (1) enhancement of hypoxic tolerance of neurons by deletion of the calcium channel subunit Orai2 and (2) blocking of detrimental lymphocyte-platelet responses. However, until now, no preclinical stroke study has assessed the potential of combining neuroprotective with anti-thrombo-inflammatory interventions to augment therapeutic effects. We induced focal cerebral ischemia in Orai2-deficient (

Indexed as

Brain IschemiaORAI2 ProteinStrokeAnimalsBlood PlateletsDisease Models, AnimalInfarction, Middle Cerebral ArteryMiceMice, KnockoutNeuroprotectionORAI2 ProteinOrai2 protein, mouseglycoprotein receptor Ibαischemic penumbraischemic strokemiddle cerebral artery occlusionOrai2thrombo-inflammation

Identifiers

PMID36012752
PMCPMC9409377
OpenAlexW4292687235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.