Evidence map›Paper›PMID 36012735›Full record

ReviewInternational journal of molecular sciences2022

Vaccine for Diabetes-Where Do We Stand?

Dinesh Kumar Chellappan, Richie R Bhandare, Afzal B Shaik, Krishna Prasad, Nurfatihah Azlyna Ahmad Suhaimi, Wei Sheng Yap, Arpita Das, Pradipta Banerjee, Nandini Ghosh, Tanner Guith and 8 more

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Exploring the Frontiers of Diabetes Vaccination.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 5 countries.

Dinesh Kumar ChellappanDepartment of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia.ORCID 0000-0001-5567-6663
Richie R BhandareDepartment of Pharmaceutical Sciences, College of Pharmacy & Health Sciences, Ajman University, Al-Jruf, Ajman P.O. Box 346, United Arab Emirates.
Afzal B ShaikSt. Mary's College of Pharmacy, St. Mary's Group of Institutions Guntur, Chebrolu, Guntur 522212, India.ORCID 0000-0002-9036-1963
Krishna PrasadDepartment of Clinical Sciences, College of Dentistry, Centre of Medical and Bio-Allied Health Science Research, Ajman University, Al-Jruf, Ajman P.O. Box 346, United Arab Emirates.
Nurfatihah Azlyna Ahmad SuhaimiSchool of Health Sciences, International Medical University, Kuala Lumpur 57000, Malaysia.
Wei Sheng YapSchool of Health Sciences, International Medical University, Kuala Lumpur 57000, Malaysia.
Arpita DasDepartment of Biotechnology, Adamas University, Kolkata 700126, India.ORCID 0000-0002-8665-3074
Pradipta BanerjeeDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-2609-8849
Nandini GhoshDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Tanner GuithDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Amitava DasDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Sarannya BalakrishnanSchool of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia.
Mayuren CandasamyDepartment of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia.ORCID 0000-0002-6745-9815
Jayashree MayurenDepartment of Pharmaceutical Technology, School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia.
Kishneth PalanivelooC302, Institute of Ocean and Earth Sciences, University of Malaya, Kuala Lumpur 50603, Malaysia.ORCID 0000-0003-0466-2602
Gaurav GuptaSchool of Pharmacy, Suresh Gyan Vihar University, Jaipur 302017, India.
Sachin Kumar SinghSchool of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T Road, Phagwara 144411, India.ORCID 0000-0003-3823-6572
Kamal DuaAustralian Research Centre in Complementary and Integrative Medicine, Faculty of Health, University of Technology Sydney, Sydney, NSW 2007, Australia.ORCID 0000-0002-7507-1159
IMU University · MYIndiana University School of MedicineAdamas University · INAjman University · AELovely Professional University · INSCMS Group of Educational Institutions · INUniversity of Malaya · MYUniversity of Technology Sydney · AUUttaranchal University · IN

Funding

Deanship of Graduate Studies and Research, Ajman University None
6 · The paper itself

Abstract

Diabetes is an endocrinological disorder with a rapidly increasing number of patients globally. Over the last few years, the alarming status of diabetes has become a pivotal factor pertaining to morbidity and mortality among the youth as well as middle-aged people. Current developments in our understanding related to autoimmune responses leading to diabetes have developed a cause for concern in the prospective usage of immunomodulatory agents to prevent diabetes. The mechanism of action of vaccines varies greatly, such as removing autoreactive T cells and inhibiting the interactions between immune cells. Currently, most developed diabetes vaccines have been tested in animal models, while only a few human trials have been completed with positive outcomes. In this review, we investigate the undergoing clinical trial studies for the development of a prototype diabetes vaccine.

Indexed as

Diabetes Mellitus, Type 2VaccinesAdolescentAnimalsAutoimmunityHumansMiddle AgedProspective StudiesT-LymphocytesVaccinesclinical trialsdiabetesGLPinsulinvaccines

Identifiers

PMID36012735
PMCPMC9409121
OpenAlexW4292582542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.