Evidence map›Paper›PMID 36012705›Full record

ArticleInternational journal of molecular sciences2022

β-Galactosylceramidase Deficiency Causes Upregulation of Long Pentraxin-3 in the Central Nervous System of Krabbe Patients and

Daniela Coltrini, Adwaid Manu Krishna Chandran, Mirella Belleri, Pietro L Poliani, Manuela Cominelli, Francesca Pagani, Miriam Capra, Stefano Calza, Simona Prioni, Laura Mauri and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Neurodegenerative Diseases in Children: A Comprehensive Review.International journal of molecular sciences · 2026
    Review
  2. Zebra-Sphinx: Modeling Sphingolipidoses in Zebrafish.International journal of molecular sciences · 2023
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Daniela ColtriniDepartment of Molecular and Translational Medicine, School of Medicine, University of Brescia, 25123 Brescia, Italy.
Adwaid Manu Krishna ChandranDepartment of Molecular and Translational Medicine, School of Medicine, University of Brescia, 25123 Brescia, Italy.
Mirella BelleriDepartment of Molecular and Translational Medicine, School of Medicine, University of Brescia, 25123 Brescia, Italy.
Pietro L PolianiDepartment of Molecular and Translational Medicine, School of Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-5662-8978
Manuela CominelliDepartment of Molecular and Translational Medicine, School of Medicine, University of Brescia, 25123 Brescia, Italy.
Francesca PaganiDepartment of Molecular and Translational Medicine, School of Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-1671-5671
Miriam CapraDepartment of Molecular and Translational Medicine, School of Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0003-4941-6739
Stefano CalzaDepartment of Molecular and Translational Medicine, School of Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0003-4996-7995
Simona PrioniDepartment of Medical Biotechnology and Translational Medicine, University of Milan, 20133 Milan, Italy.
Laura MauriDepartment of Medical Biotechnology and Translational Medicine, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-4194-4804
Alessandro PrinettiDepartment of Medical Biotechnology and Translational Medicine, University of Milan, 20133 Milan, Italy.ORCID 0000-0003-0252-2593
Julia K KoflerDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224-1334, USA.
Maria L EscolarDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224-1334, USA.ORCID 0000-0003-1530-6777
Marco PrestaDepartment of Molecular and Translational Medicine, School of Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-4398-8376
University of Brescia · ITUniversity of Milan · ITUniversity of Pittsburgh · US

Funding

Associazione "dedicato A te" N/AItalian Association for Cancer Research AIRC, IG 23116The Legacy of Angels Foundation, Partners for Krabbe Research N/A
6 · The paper itself

Abstract

Globoid cell leukodystrophy (GLD), or Krabbe disease, is a neurodegenerative sphingolipidosis caused by genetic deficiency of lysosomal

Indexed as

C-Reactive ProteinGalactosylceramidaseLeukodystrophy, Globoid CellNerve Tissue ProteinsAnimalsCentral Nervous SystemDisease Models, AnimalHumansMiceMice, TransgenicPentraxinsPsychosineUp-RegulationC-Reactive ProteinGalactosylceramidaseNerve Tissue ProteinsPentraxinsPsychosineCNSGALCKrabbe diseaseneuroinflammationPTX3sphingolipidosis

Identifiers

PMID36012705
PMCPMC9409448
OpenAlexW4293030649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.