Evidence map›Paper›PMID 36012679›Full record

ArticleInternational journal of molecular sciences2022

Chronic N-Acetylcysteine Treatment Prevents Amphetamine-Induced Hyperactivity in Heterozygous

Chuan-Ching Lai, Rathinasamy Baskaran, Chih-Yu Tsao, Li-Heng Tuan, Pei-Fen Siow, Mahalakshmi Palani, Lukas Jyuhn-Hsiarn Lee, Chih-Min Liu, Hai-Gwo Hwu, Li-Jen Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. N-acetyl cysteine through modulation of HDACIBRO neuroscience reports · 2025
    Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Chuan-Ching LaiDepartment of Post-Baccalaureate Veterinary Medicine, Asia University, Taichung 413305, Taiwan.
Rathinasamy BaskaranDepartment of Bioinformatics and Medical Engineering, Asia University, Taichung 413305, Taiwan.ORCID 0000-0002-2676-7379
Chih-Yu TsaoGraduate Institute of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei 100233, Taiwan.
Li-Heng TuanSchool of Medicine, National Tsing Hua University, Hsinchu 300044, Taiwan.
Pei-Fen SiowGraduate Institute of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei 100233, Taiwan.ORCID 0000-0003-2864-6324
Mahalakshmi PalaniGraduate Institute of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei 100233, Taiwan.
Lukas Jyuhn-Hsiarn LeeInstitute of Environmental Health Sciences, National Health Research Institutes, Miaoli 350401, Taiwan.ORCID 0000-0003-1095-6877
Chih-Min LiuDepartment of Psychiatry, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei 100233, Taiwan.ORCID 0000-0001-7016-8990
Hai-Gwo HwuDepartment of Psychiatry, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei 100233, Taiwan.
Li-Jen LeeGraduate Institute of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei 100233, Taiwan.ORCID 0000-0001-9108-3654
National Taiwan University · TWNational Health Research Institutes · TWAsia University · TWNational Tsing Hua University · TW

Funding

Ministry of Science and Technology of the Republic of China 105-2628-B-002-004-MY3Ministry of Science and Technology of the Republic of China 108-2320-B-002-066-MY3
6 · The paper itself

Abstract

Symptoms of schizophrenia (SZ) typically emerge during adolescence to young adulthood, which gives a window before full-blown psychosis for early intervention. Strategies for preventing the conversion from the prodromal phase to the psychotic phase are warranted. Heterozygous (Het)

Indexed as

AmphetamineSchizophreniaAcetylcysteineAnimalsDisease Models, AnimalDopamineFemaleGlycogen Synthase Kinase 3HumansMiceNerve Tissue ProteinsPregnancyReceptors, DopamineAcetylcysteineAmphetamineDISC1 protein, humanDisc1 protein, mouseDopamineGlycogen Synthase Kinase 3Nerve Tissue ProteinsReceptors, Dopamineanimal modeldopamine receptorprodromal phaseschizophreniastriatum

Identifiers

PMID36012679
PMCPMC9408838
OpenAlexW4293780043

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.