Evidence map›Paper›PMID 36012557›Full record

ArticleInternational journal of molecular sciences2022

Deletion of Macrophage-Specific Glycogen Synthase Kinase (GSK)-3α Promotes Atherosclerotic Regression in

Sarvatit Patel, Lauren Mastrogiacomo, Madison Fulmer, Yuanyuan Shi, Geoff H Werstuck

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sarvatit PatelThrombosis and Atherosclerosis Research Institute, 237 Barton Street E, Hamilton, ON L9L 2X2, Canada.
Lauren MastrogiacomoThrombosis and Atherosclerosis Research Institute, 237 Barton Street E, Hamilton, ON L9L 2X2, Canada.
Madison FulmerThrombosis and Atherosclerosis Research Institute, 237 Barton Street E, Hamilton, ON L9L 2X2, Canada.
Yuanyuan ShiThrombosis and Atherosclerosis Research Institute, 237 Barton Street E, Hamilton, ON L9L 2X2, Canada.
Geoff H WerstuckThrombosis and Atherosclerosis Research Institute, 237 Barton Street E, Hamilton, ON L9L 2X2, Canada.ORCID 0000-0002-7843-885X
Thrombosis and Atherosclerosis Research Institute · CA

Funding

CIHR PJT-166092Heart and Stroke Foundation G20- 469 0029355
6 · The paper itself

Abstract

Recent evidence from our laboratory suggests that impeding ER stress-GSK3α/β signaling attenuates the progression and development of atherosclerosis in mouse model systems. The objective of this study was to determine if the tissue-specific genetic ablation of GSK3α/β could promote the regression of established atherosclerotic plaques. Five-week-old low-density lipoprotein receptor knockout (

Indexed as

AtherosclerosisGlycogen Synthase Kinase 3Plaque, AtheroscleroticAnimalsAortaDiet, High-FatDisease Models, AnimalFemaleGene DeletionMacrophagesMiceMice, Inbred C57BLMice, KnockoutProtein Serine-Threonine KinasesReceptors, LDLGlycogen Synthase Kinase 3Protein Serine-Threonine KinasesReceptors, LDLatherosclerosisglycogen synthase kinase (GSK)-3α/βinflammationmacrophagesmice modelmigrationregressionreverse cholesterol transport

Identifiers

PMID36012557
PMCPMC9409307
OpenAlexW4292247946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.