Evidence map›Paper›PMID 36012553›Full record

ArticleInternational journal of molecular sciences2022

Targeted Modification of Mammalian DNA by a Novel Type V Cas12a Endonuclease from

Ruslan Vasilev, Natalia Gunitseva, Regina Shebanova, Aleksei Korzhenkov, Anna Vlaskina, Marta Evteeva, Irina Polushkina, Natalia Nikitchina, Stepan Toshchakov, Piotr Kamenski and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. A New RNA-Dependent Cas12g Nuclease.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Ruslan VasilevKurchatov Genomics Center, National Research Center "Kurchatov Institute", 123098 Moscow, Russia.ORCID 0000-0002-6839-905X
Natalia GunitsevaKurchatov Genomics Center, National Research Center "Kurchatov Institute", 123098 Moscow, Russia.
Regina ShebanovaCenter of Life Sciences, Skolkovo Institute of Science and Technology, 143026 Moscow, Russia.
Aleksei KorzhenkovKurchatov Genomics Center, National Research Center "Kurchatov Institute", 123098 Moscow, Russia.
Anna VlaskinaKurchatov Genomics Center, National Research Center "Kurchatov Institute", 123098 Moscow, Russia.
Marta EvteevaKurchatov Genomics Center, National Research Center "Kurchatov Institute", 123098 Moscow, Russia.ORCID 0000-0003-1771-6382
Irina PolushkinaKurchatov Genomics Center, National Research Center "Kurchatov Institute", 123098 Moscow, Russia.
Natalia NikitchinaCenter of Life Sciences, Skolkovo Institute of Science and Technology, 143026 Moscow, Russia.
Stepan ToshchakovKurchatov Genomics Center, National Research Center "Kurchatov Institute", 123098 Moscow, Russia.ORCID 0000-0001-7549-3450
Piotr KamenskiFaculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0002-0621-4611
Maxim PatrushevKurchatov Genomics Center, National Research Center "Kurchatov Institute", 123098 Moscow, Russia.
Ilya MazuninCenter of Life Sciences, Skolkovo Institute of Science and Technology, 143026 Moscow, Russia.ORCID 0000-0002-5448-9679
Kurchatov Institute · RUSkolkovo Institute of Science and Technology · RULomonosov Moscow State University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type V Cas12a nucleases are DNA editors working in a wide temperature range and using expanded protospacer-adjacent motifs (PAMs). Though they are widely used, there is still a demand for discovering new ones. Here, we demonstrate a novel ortholog from

Indexed as

CRISPR-Cas SystemsEndonucleasesAcidaminococcusAnimalsDNAGene EditingHumansMammalsRuminococcusDNAEndonucleasesCas endonucleaseCRISPRgenome editingmammalian cellssite-directed mutagenesis

Identifiers

PMID36012553
PMCPMC9409102
OpenAlexW4292247501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.