Evidence map›Paper›PMID 36012525›Full record

ArticleInternational journal of molecular sciences2022

New, Fully Implantable Device for Selective Clearance of CSF-Target Molecules: Proof of Concept in a Murine Model of Alzheimer's Disease.

María Almudena Coto-Vilcapoma, Juan Castilla-Silgado, Benjamín Fernández-García, Paola Pinto-Hernández, Raffaela Cipriani, Estibaliz Capetillo-Zarate, Manuel Menéndez-González, Marco Álvarez-Vega, Cristina Tomás-Zapico

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Cerebellar cortical amyloid deposition biasesEuropean journal of nuclear medicine and molecular imaging · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

María Almudena Coto-VilcapomaDepartamento de Biología Funcional, Área de Fisiología, Universidad de Oviedo, 33006 Oviedo, Spain.ORCID 0000-0002-9856-6939
Juan Castilla-SilgadoDepartamento de Biología Funcional, Área de Fisiología, Universidad de Oviedo, 33006 Oviedo, Spain.
Benjamín Fernández-GarcíaInstituto de Investigación Sanitaria del Principado de Asturias, 33011 Oviedo, Spain.ORCID 0000-0002-2391-680X
Paola Pinto-HernándezDepartamento de Biología Funcional, Área de Fisiología, Universidad de Oviedo, 33006 Oviedo, Spain.
Raffaela CiprianiAchucarro Basque Center for Neuroscience, Departamento de Neurociencias, Universidad del País Vasco (UPV/EHU), 48940 Leioa, Spain.
Estibaliz Capetillo-ZarateAchucarro Basque Center for Neuroscience, Departamento de Neurociencias, Universidad del País Vasco (UPV/EHU), 48940 Leioa, Spain.ORCID 0000-0002-8416-0495
Manuel Menéndez-GonzálezInstituto de Investigación Sanitaria del Principado de Asturias, 33011 Oviedo, Spain.ORCID 0000-0002-5218-0774
Marco Álvarez-VegaServicio de Neurocirugía, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.
Cristina Tomás-ZapicoDepartamento de Biología Funcional, Área de Fisiología, Universidad de Oviedo, 33006 Oviedo, Spain.ORCID 0000-0001-7823-0410
Universidad de Oviedo · ESIkerbasque · ESUniversity of the Basque Country · ES

Funding

Foundation for the Promotion of Applied Scientific Research and Technology in Asturias AYUD/2021/57540Instituto de Salud Carlos III DTS19-00071
6 · The paper itself

Abstract

We have previously proposed a radical change in the current strategy to clear pathogenic proteins from the central nervous system (CNS) based on the

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsBrainDisease Models, AnimalMiceMice, TransgenicPlaque, AmyloidAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAlzheimerbeta-amyloidblood–brain barriercerebrospinal fluidCSF-sinkimmunotherapyimplantable devicenanoporous membranes

Identifiers

PMID36012525
PMCPMC9408974
OpenAlexW4292164053

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.