Evidence map›Paper›PMID 36012497›Full record

ArticleInternational journal of molecular sciences2022

Knockdown of the

Sam Schellens, Cynthia Lenaerts, María Del Rocío Pérez Baca, Dorien Cools, Paulien Peeters, Elisabeth Marchal, Jozef Vanden Broeck

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Functional Characterization ofInternational journal of molecular sciences · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Ecdysteroid Biosynthesis Halloween GeneInternational journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sam SchellensMolecular Developmental Physiology and Signal Transduction, KU Leuven, Naamsestraat 59 Box 2465, B-3000 Leuven, Belgium.ORCID 0000-0002-9588-3963
Cynthia LenaertsMolecular Developmental Physiology and Signal Transduction, KU Leuven, Naamsestraat 59 Box 2465, B-3000 Leuven, Belgium.
María Del Rocío Pérez BacaMolecular Developmental Physiology and Signal Transduction, KU Leuven, Naamsestraat 59 Box 2465, B-3000 Leuven, Belgium.ORCID 0000-0002-0117-9255
Dorien CoolsMolecular Developmental Physiology and Signal Transduction, KU Leuven, Naamsestraat 59 Box 2465, B-3000 Leuven, Belgium.
Paulien PeetersMolecular Developmental Physiology and Signal Transduction, KU Leuven, Naamsestraat 59 Box 2465, B-3000 Leuven, Belgium.
Elisabeth MarchalMolecular Developmental Physiology and Signal Transduction, KU Leuven, Naamsestraat 59 Box 2465, B-3000 Leuven, Belgium.
Jozef Vanden BroeckMolecular Developmental Physiology and Signal Transduction, KU Leuven, Naamsestraat 59 Box 2465, B-3000 Leuven, Belgium.ORCID 0000-0001-7653-0516
KU Leuven · BEIMEC · BE

Funding

European Union 634361KU Leuven C14/15/050KU Leuven C14/19/069KU Leuven GOA/11/02KU Leuven PDM 18/111Research Foundation - Flanders 121547Research Foundation - Flanders 1S42119NResearch Foundation - Flanders G090919NResearch Foundation - Flanders G0F2417N
6 · The paper itself

Abstract

Ecdysteroids are widely investigated for their role during the molting cascade in insects; however, they are also involved in the development of the female reproductive system. Ecdysteroids are synthesized from cholesterol, which is further converted via a series of enzymatic steps into the main molting hormone, 20-hydoxyecdysone. Most of these biosynthetic conversion steps involve the activity of cytochrome P450 (CYP) hydroxylases, which are encoded by the

Indexed as

EcdysteroidsGrasshoppersAnimalsCytochrome P-450 Enzyme SystemFemaleInsect ProteinsOocytesOogenesisOvipositionCytochrome P-450 Enzyme SystemEcdysteroidsInsect Proteinsbiosynthesisecdysoneecdysteriodhemimetabolahormoneinsectoogenesisreproduction

Identifiers

PMID36012497
PMCPMC9408901
OpenAlexW4292163046

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.