Evidence map›Paper›PMID 36012450›Full record

ReviewInternational journal of molecular sciences2022

Neuronal Roles of the Multifunctional Protein Dipeptidyl Peptidase-like 6 (DPP6).

Cole Malloy, Maisie Ahern, Lin Lin, Dax A Hoffman

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Neural cell state modulation bybioRxiv : the preprint server for biology · 2026
    Article
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  11. Genome-Wide Epistatic Network Analyses of Semantic Fluency in Older Adults.International journal of molecular sciences · 2024
    Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Cole MalloyMolecular Neurophysiology and Biophysics Section, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-3622-798X
Maisie AhernMolecular Neurophysiology and Biophysics Section, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Lin LinMolecular Neurophysiology and Biophysics Section, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-9332-0438
Dax A HoffmanMolecular Neurophysiology and Biophysics Section, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-6999-2157
National Institutes of Health · US

Funding

Potassium Channels and Dendritic Function in Hippocampal Pyramidal NeuronsZIAHD008755 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI HOFFMAN, DAX A · 2009 to 2025
$29.6M
Eunice Kennedy Shriver National Institute of Child Health and Human Development Z01-HD008755Intramural NIH HHS ZIA HD008755
6 · The paper itself

Abstract

The concerted action of voltage-gated ion channels in the brain is fundamental in controlling neuronal physiology and circuit function. Ion channels often associate in multi-protein complexes together with auxiliary subunits, which can strongly influence channel expression and function and, therefore, neuronal computation. One such auxiliary subunit that displays prominent expression in multiple brain regions is the Dipeptidyl aminopeptidase-like protein 6 (DPP6). This protein associates with A-type K

Indexed as

Dipeptidyl-Peptidases and Tripeptidyl-PeptidasesShal Potassium ChannelsKv Channel-Interacting ProteinsNerve Tissue ProteinsNeuronsDipeptidyl-Peptidases and Tripeptidyl-PeptidasesKv Channel-Interacting ProteinsNerve Tissue ProteinsShal Potassium ChannelsA-type K+ channelDPP6Kv4.2neuronal developmentneuronal excitabilitysynaptogenesisvoltage-gated potassium channel

Identifiers

PMID36012450
PMCPMC9409431
OpenAlexW4292295291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.