Evidence map›Paper›PMID 36012357›Full record

ReviewInternational journal of molecular sciences2022

Role of MicroRNA-7 (MiR-7) in Cancer Physiopathology.

Mario Morales-Martínez, Mario I Vega

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  4. Review
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  6. Article
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  11. Review
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  13. Review
  14. Anti-cancer agents in medicinal chemistry · 2025
    Article
  15. Article
  16. Role of miRNA‑122 in cancer (Review).International journal of oncology · 2024
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Mario Morales-MartínezMolecular Signal Pathway in Cancer Laboratory, UIMEO, Oncology Hospital, Siglo XXI National Medical Center, IMSS, Mexico City 06720, Mexico.
Mario I VegaMolecular Signal Pathway in Cancer Laboratory, UIMEO, Oncology Hospital, Siglo XXI National Medical Center, IMSS, Mexico City 06720, Mexico.ORCID 0000-0002-3932-2483
Centro Medico Nacional Siglo XXI · MXRonald Reagan UCLA Medical Center · US

Funding

Sensitivity of multiple myeloma cells to mTOR inhibitorsR01CA111448 · NCI · BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE · PI LICHTENSTEIN, ALAN K · 2005 to 2016
$1.9M
Targeting DEPTOR in multiple myelomaR01CA211562 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LICHTENSTEIN, ALAN K · 2017 to 2021
$1.4M
NIH HHS RO1CA111448NIH HHS RO1CA211562, R21CA168491, RO1CA217820
6 · The paper itself

Abstract

miRNAs are non-coding RNA sequences of approximately 22 nucleotides that interact with genes by inhibiting their translation through binding to their 3' or 5' UTR regions. Following their discovery, the role they play in the development of various pathologies, particularly cancer, has been studied. In this context, miR-7 is described as an important factor in the development of cancer because of its role as a tumor suppressor, regulating a large number of genes involved in the development and progression of cancer. Recent data support the function of miR-7 as a prognostic biomarker in cancer, and miR-7 has been proposed as a strategy in cancer therapy. In this work, the role of miR-7 in various types of cancer is reviewed, illustrating its regulation, direct targets, and effects, as well as its possible relationship to the clinical outcome of cancer patients.

Indexed as

MicroRNAsNeoplasms5' Untranslated RegionsCell Line, TumorGene Expression Regulation, NeoplasticGenes, Tumor SuppressorHumans5' Untranslated RegionsMicroRNAsMIRN7-1 microRNA, humancancercancer progressionclinical implicationgene expressionmiR-7

Identifiers

PMID36012357
PMCPMC9408913
OpenAlexW4291465130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.