Evidence map›Paper›PMID 36012304›Full record

ArticleInternational journal of molecular sciences2022

Small-Molecules as Chemiluminescent Probes to Detect Lipase Activity.

Paolo La Rocca, Alessandra Mingione, Silvana Casati, Roberta Ottria, Pietro Allevi, Pierangela Ciuffreda, Paola Rota

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Paolo La RoccaDipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, 20133 Milano, Italy.ORCID 0000-0002-1872-9524
Alessandra MingioneDipartimento di Scienze Biomediche e Cliniche, Università di Milano, 20157 Milano, Italy.ORCID 0000-0001-8008-0191
Silvana CasatiDipartimento di Scienze Biomediche e Cliniche, Università di Milano, 20157 Milano, Italy.ORCID 0000-0002-3865-0709
Roberta OttriaDipartimento di Scienze Biomediche e Cliniche, Università di Milano, 20157 Milano, Italy.ORCID 0000-0003-3379-0582
Pietro AlleviDipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano, 20133 Milano, Italy.
Pierangela CiuffredaDipartimento di Scienze Biomediche e Cliniche, Università di Milano, 20157 Milano, Italy.ORCID 0000-0003-2227-1373
Paola RotaDipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano, 20133 Milano, Italy.ORCID 0000-0001-5795-4989

Funding

This research was funded by Università degli Studi di Milano, Finanziamento di Ateneo - Linea 3 - Bando SEED - PSR 2019 funding to PC and PR RV_PSR_SEED_2019_SCACC
6 · The paper itself

Abstract

The set-up of highly sensitive detection tools to evaluate lipase activity remains a central goal in different fields. In this context, we proposed new chemiluminescent 1,2-dioxetane luminophores, sharing an octanoyl triggerable group, to monitor lipase activity. We herein report the synthesis and both the evaluation of their luminescence emission profile and their enzyme-substrate specificity, generated by three different commercial lipases (

Indexed as

LuminescenceLuminescent MeasurementsAnimalsCandidaLipaseSubstrate SpecificitySwineLipase1,2-dioxetaneschemiluminescenceflash-luminescenceglow-luminescencelipase

Identifiers

PMID36012304
PMCPMC9409280

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.