Evidence map›Paper›PMID 36012269›Full record

ReviewInternational journal of molecular sciences2022

Upconversion Nanostructures Applied in Theranostic Systems.

Chao Lu, Etienne Joulin, Howyn Tang, Hossein Pouri, Jin Zhang

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Nanoparticle-Based Techniques for Bladder Cancer Imaging: A Review.International journal of molecular sciences · 2023
    Review
  7. Chemical and Colloidal Stability of Polymer-Coated NaYFInternational journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chao LuDepartment of Chemical and Biochemical Engineering, University of Western Ontario, London, ON N6A 5B9, Canada.ORCID 0000-0002-7858-7927
Etienne JoulinDepartment of Chemical and Biochemical Engineering, University of Western Ontario, London, ON N6A 5B9, Canada.
Howyn TangSchool of Biomedical Engineering, University of Western Ontario, London, ON N6A 5B9, Canada.
Hossein PouriDepartment of Chemical and Biochemical Engineering, University of Western Ontario, London, ON N6A 5B9, Canada.
Jin ZhangDepartment of Chemical and Biochemical Engineering, University of Western Ontario, London, ON N6A 5B9, Canada.ORCID 0000-0002-6875-8008

Funding

Natural Sciences and Engineering Research Council of Canada RGPIN-2021-03859
6 · The paper itself

Abstract

Upconversion (UC) nanostructures, which can upconvert near-infrared (NIR) light with low energy to visible or UV light with higher energy, are investigated for theranostic applications. The surface of lanthanide (Ln)-doped UC nanostructures can be modified with different functional groups and bioconjugated with biomolecules for therapeutic systems. On the other hand, organic molecular-based UC nanostructures, by using the triplet-triplet annihilation (TTA) UC mechanism, have high UC quantum yields and do not require high excitation power. In this review, the major UC mechanisms in different nanostructures have been introduced, including the Ln-doped UC mechanism and the TTA UC mechanism. The design and fabrication of Ln-doped UC nanostructures and TTA UC-based UC nanostructures for theranostic applications have been reviewed and discussed. In addition, the current progress in the application of UC nanostructures for diagnosis and therapy has been summarized, including tumor-targeted bioimaging and chemotherapy, image-guided diagnosis and phototherapy, NIR-triggered controlled drug releasing and bioimaging. We also provide insight into the development of emerging UC nanostructures in the field of theranostics.

Indexed as

Lanthanoid Series ElementsNanostructuresNeoplasmsHumansPrecision MedicineLanthanoid Series Elementsbiosensingdrug carrierslanthanide-doped upconversion nanoparticlesmetal-organic frameworksNIR-triggered drug deliverytheranostic systemtriplet-triplet annihilation upconversionupconversion nanomaterials

Identifiers

PMID36012269
PMCPMC9409402

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.