Evidence map›Paper›PMID 36012241›Full record

ArticleInternational journal of molecular sciences2022

Synthesis and NLRP3-Inflammasome Inhibitory Activity of the Naturally Occurring Velutone F and of Its Non-Natural Regioisomeric Chalconoids.

Tiziano De Ventura, Mariasole Perrone, Sonia Missiroli, Paolo Pinton, Paolo Marchetti, Giovanni Strazzabosco, Giulia Turrin, Davide Illuminati, Virginia Cristofori, Anna Fantinati and 4 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Chalcones and Gastrointestinal Cancers: Experimental Evidence.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tiziano De VenturaDepartment of Chemistry, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.ORCID 0000-0003-0534-9087
Mariasole PerroneDepartment of Medical Sciences, Section of Experimental Medicine, University of Ferrara, Via Fossato di Mortara, 64/b, 44121 Ferrara, Italy.ORCID 0000-0002-8617-2705
Sonia MissiroliDepartment of Medical Sciences, Section of Experimental Medicine, University of Ferrara, Via Fossato di Mortara, 64/b, 44121 Ferrara, Italy.
Paolo PintonDepartment of Medical Sciences, Section of Experimental Medicine, University of Ferrara, Via Fossato di Mortara, 64/b, 44121 Ferrara, Italy.ORCID 0000-0001-7108-6508
Paolo MarchettiDepartment of Chemistry, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.ORCID 0000-0002-4040-4961
Giovanni StrazzaboscoDepartment of Chemistry, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.ORCID 0000-0001-7227-7939
Giulia TurrinDepartment of Chemistry, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.ORCID 0000-0002-1777-8279
Davide IlluminatiDepartment of Chemistry, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.ORCID 0000-0002-0321-1941
Virginia CristoforiDepartment of Chemistry, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.ORCID 0000-0002-6837-6042
Anna FantinatiDepartment of Environmental and Prevention Sciences, University of Ferrara, Via Fossato di Mortara 17, 44121 Ferrara, Italy.ORCID 0000-0003-0437-5670
Martina FabbriDepartment of Chemistry, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.ORCID 0000-0003-0069-6768
Carlotta GiorgiDepartment of Medical Sciences, Section of Experimental Medicine, University of Ferrara, Via Fossato di Mortara, 64/b, 44121 Ferrara, Italy.ORCID 0000-0002-2494-7405
Claudio TrapellaDepartment of Chemistry, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.ORCID 0000-0002-6666-143X
Vinicio ZaniratoDepartment of Chemistry, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.

Funding

European Research Council 853057-InflaPMLItalian Association for Cancer Research IG-23670, IG-19803Italian Ministry of Health GR-2019-12369646Itlian Ministry Of University PRIN PRIN2017E5L5P3 and prin20177E9EPY
6 · The paper itself

Abstract

Plant-derived remedies rich in chalcone-based compounds have been known for centuries in the treatment of specific diseases, and nowadays, the fascinating chalcone framework is considered a useful and, above all, abundant natural chemotype. Velutone F, a new chalconoid from

Indexed as

ChalconesInflammasomesFlavonoidsNLR Family, Pyrin Domain-Containing 3 ProteinChalconesFlavonoidsInflammasomesNLR Family, Pyrin Domain-Containing 3 Proteinchalcone-based compoundsflavonoidNLRP3-inflammasome inhibitors

Identifiers

PMID36012241
PMCPMC9409317

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.