Evidence map›Paper›PMID 36012158›Full record

ArticleInternational journal of molecular sciences2022

Hepatocyte Nuclear Factor 1α Proinflammatory Effect Linked to the Overexpression of Liver Nuclear Factor-κB in Experimental Model of Chronic Kidney Disease.

Elzbieta Sucajtys-Szulc, Alicja Debska-Slizien, Boleslaw Rutkowski, Marek Szolkiewicz, Julian Swierczynski, Ryszard Tomasz Smolenski

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Elzbieta Sucajtys-SzulcDepartment of Nephrology, Transplantology, and Internal Medicine, Medical University of Gdansk, Smoluchowskiego 17, 80-214 Gdansk, Poland.ORCID 0000-0002-0955-6772
Alicja Debska-SlizienDepartment of Nephrology, Transplantology, and Internal Medicine, Medical University of Gdansk, Smoluchowskiego 17, 80-214 Gdansk, Poland.ORCID 0000-0001-8210-8063
Boleslaw RutkowskiDepartment of Nephrology, Transplantology, and Internal Medicine, Medical University of Gdansk, Smoluchowskiego 17, 80-214 Gdansk, Poland.
Marek SzolkiewiczDepartment of Nephrology, Transplantology, and Internal Medicine, Medical University of Gdansk, Smoluchowskiego 17, 80-214 Gdansk, Poland.ORCID 0000-0002-0367-4014
Julian SwierczynskiKoszalin State Higher Vocational School, Lesna 1, 75-582 Koszalin, Poland.
Ryszard Tomasz SmolenskiDepartment of Biochemistry, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland.ORCID 0000-0002-0190-9414
Gdańsk Medical University · PLState Higher Vocational School in Koszalin · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic kidney disease (CKD) is associated with low-grade inflammation that activates nuclear factor-κB (NF-κB), which upregulates the expression of numerous NF-κB responsive genes, including the genes encoding IL-6, ICAM-1, VCAM-1, and MCP-1. Herein, we found the coordinated overexpression of genes encoding RelA/p65 (a subunit of NF-κB) and HNF1α in the livers of chronic renal failure (CRF) rats-an experimental model of CKD. The coordinated overexpression of

Indexed as

NF-kappa BRenal Insufficiency, ChronicAnimalsCell Line, TumorHepatocyte Nuclear Factor 1-alphaHumansIntercellular Adhesion Molecule-1Interleukin-6LiverModels, TheoreticalRatsRNA, MessengerTranscription Factor RelAVascular Cell Adhesion Molecule-1Hepatocyte Nuclear Factor 1-alphaIntercellular Adhesion Molecule-1Interleukin-6NF-kappa BRNA, MessengerTranscription Factor RelAVascular Cell Adhesion Molecule-1chronic kidney diseaseclofibratehepatocyte nuclear factor 1αintercellular cell adhesion molecule 1interleukin-6monocyte chemoattractant protein 1nuclear factor–κBvascular cell adhesion molecule 1

Identifiers

PMID36012158
PMCPMC9408856
OpenAlexW4291001712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.