ArticleInternational journal of environmental research and public health2022
Multimorbidity Clusters in the Oldest Old: Results from the EpiChron Cohort.
Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- A systematic review and meta-analysis of disease clusters in multimorbidity.Nature communications · 2025Pooled it
- Relevance of Kidney-Metabolic Multimorbidity Pattern to Metabolic Health and Mortality Among Elderly Inpatients in China.Food science & nutrition · 2026Article
- Lifestyle and Chronic Comorbidity in Relation to Healthy Ageing in Community-Dwelling People Aged 80 and over: Preliminary Study from a Primary Health Care Service in Southern Spain.Healthcare (Basel, Switzerland) · 2026Article
- Genetic, Socioecological, and Health Research on Extreme Longevity in Semisupercentenarians and Supercentenarians: A Scoping Review.Journal of aging research · 2026Article
- Disease accumulation and distribution across the lifespan in Swedish centenarians and non-centenarians: a nationwide life course comparison of longevity and health resilience.EClinicalMedicine · 2025Article
- Differential Distributions: A refined methodology to indirect reference interval estimation by including Patient's health status according to associated ICD-10 codes.Practical laboratory medicine · 2025Article
- Multimorbidity clusters: translating research evidence into actionable interventions.European geriatric medicine · 2025Article
- Electronic Health Records: A Gateway to AI-Driven Multimorbidity Solutions-A Comprehensive Systematic Review.Journal of clinical medicine · 2025Review
- Cluster and survival analysis of UK biobank data reveals associations between physical multimorbidity clusters and subsequent depression.Communications medicine · 2025Article
- Charting the Pathways of Cardiometabolic Multimorbidity: A Systematic Review of Clinical Trajectories.Journal of clinical medicine · 2025Review
- Review
- Polypharmacy and Therapeutic Inertia in Extreme Longevity: A Potential Clinical Ageism Scenario Secondary to Important Gaps in Clinical Evidence.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2024Article
- Descriptive Epidemiology of New York City Older Adult Patients With Multiple Chronic Conditions.Preventing chronic disease · 2024Article
- Multimorbidity patterns and trajectories in young and middle-aged adults: a large-scale population-based cohort study.Frontiers in public health · 2024Article
- Incidence, prevalence and characteristics of multimorbidity in different age groups among urban hospitalized patients in China.Scientific reports · 2023Article
- Article
- A scoping review of the clinical application of machine learning in data-driven population segmentation analysis.Journal of the American Medical Informatics Association : JAMIA · 2023Article
- Reports of Symptoms Associated with Supraventricular Arrhythmias as a Serious Adverse Drug Reaction in the Spanish Pharmacovigilance Database.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Pharmacotherapies in Older Adults with COPD: Challenges and Opportunities.Drugs & aging · 2023Review
- Associated adverse health outcomes of polypharmacy and potentially inappropriate medications in community-dwelling older adults with diabetes.Frontiers in pharmacology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multimorbidity is challenging for both patients and healthcare systems due to its increasing prevalence and high impact on people's health and well-being. The risk of multimorbidity increases with age, but there is still more to discover regarding the clinical profile of the oldest old. In this study, we used information from the EpiChron Cohort Study to identify multimorbidity patterns in individuals who died during the period 2010-2019 at the ages of 80-89, 90-99, and ≥100. This cohort links the demographic, clinical, and drug dispensation information of public health system users in Aragón, Spain. We saw a significantly lower number of chronic diseases and drugs and a lower prevalence of polypharmacy in centenarians compared to those aged 80-99. K-means clustering revealed different multimorbidity clusters by sex and age group. We observed clusters of cardiovascular and metabolic diseases, obstructive pulmonary conditions, and neoplasms, amongst other profiles. One in three octogenarian women had a metabolic pattern (diabetes, dyslipidaemia, and other endocrine-metabolic disorders) with the highest number of diseases (up to seven) and prevalence of polypharmacy (64%). We observed clusters of dementia and genitourinary disorders in individuals on medication with anticholinergic activity. Our study offers an opportunity to better understand the urgency of adequately addressing multimorbidity in our older adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.