SynthesisInternational journal of environmental research and public health2022
Evaluating the Impact of Modic Changes on Operative Treatment in the Cervical and Lumbar Spine: A Systematic Review and Meta-Analysis.
Synthesis in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Influence of Modic changes on short-term clinical and patient-reported outcomes after anterior cervical discectomy and fusion: a retrospective cohort study.Frontiers in neurology · 2026Article
- Modic changes: From potential molecular mechanisms to future research directions (Review).Molecular medicine reports · 2025Review
- Modic Changes in Patients Who Have Undergone Anterior Cervical Discectomy and Fusion: The Correlation With Fusion Success and Subsidence.Orthopaedic surgery · 2025Article
- Chemonucleolysis for Lumbar Disc Herniation: History and Current State of the Technology.Journal of pain research · 2025Review
- Investigating the impact of cartilaginous endplate herniation on recovery from percutaneous endoscopic lumbar discectomy.Journal of orthopaedic surgery and research · 2024Article
- Novel Modic grading scoring system and its clinical validation: a preliminary investigation.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- Spinal fusion for single-level SPECT/CT positive lumbar degenerative disc disease: the SPINUS I study.Acta neurochirurgica · 2023Observational
- Modic Changes of the Cervical and Lumbar Spine and Their Effect on Neck and Back Pain: A Systematic Review and Meta-Analysis.Global spine journal · 2023Review
- Modic changes as seen on MRI are associated with nonspecific chronic lower back pain and disability.Journal of orthopaedic surgery and research · 2023Review
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Authors and funding
10 authors.
Funding
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Abstract
Modic changes (MCs) are believed to be potential pain generators in the lumbar and cervical spine, but it is currently unclear if their presence affects postsurgical outcomes. We performed a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. All studies evaluating cervical or lumbar spine postsurgical outcomes in patients with documented preoperative MCs were included. A total of 29 studies and 6013 patients with 2688 of those patients having preoperative MCs were included. Eight included studies evaluated cervical spine surgery, eleven evaluated lumbar discectomies, nine studied lumbar fusion surgery, and three assessed lumbar disc replacements. The presence of cervical MCs did not impact the clinical outcomes in the cervical spine procedures. Moreover, most studies found that MCs did not significantly impact the clinical outcomes following lumbar fusion, lumbar discectomy, or lumbar disc replacement. A meta-analysis of the relevant data found no significant association between MCs and VAS back pain or ODI following lumbar discectomy. Similarly, there was no association between MCs and JOA or neck pain following ACDF procedures. Patients with MC experienced statistically significant improvements following lumbar or cervical spine surgery. The postoperative improvements were similar to patients without MCs in the cervical and lumbar spine.
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